Title: Protective Effect of Origanum majorana L. 'Marjoram' on Various Models of Gastric Mucosal Injury in Rats Author(s)




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Title: Protective Effect of Origanum majorana L. 'Marjoram' on Various Models of Gastric Mucosal Injury in Rats










Author(s): Al-Howiriny T, Alsheikh A, Alqasoumi S , Al-Yahya M, ElTahir K, Rafatullah S.

Source: AMERICAN JOURNAL OF CHINESE MEDICINE    Volume: 37    Issue: 3    Pages: 531-545    Published: 2009  

Department: Pharmacology     

Abstract: 'Marjoram,' Origanum majorana L., a culinary aromatic medicinal herb is known to possess various therapeutic properties. We evaluated the antiulcerogenic activity of the ethanol extract in hypothermic restraint stress-, indomethacin-, necrotizing agents- (80% ethanol, 25% NaCl and 0.2 M NaOH) induced ulcers and basal gastric acid secretion using pylorus ligated Shay rat-model. Marjoram at doses of 250 and 500 mg/kg of body weight, significantly decreased the incidence of ulcers, basal gastric secretion and acid output. Furthermore, the extract replenished the ethanol-induced depleted gastric wall mucus and nonprotein sulfhydryls (NP-SH) contents and significantly lowered the increase in the concentration of malondialdehyde (MDA). Ulcer preventing potential was further confirmed by histopathological assessment. An acute toxicity test showed a large margin of safety of the extract in mice. The phytochemical screening of aerial parts of marjoram revealed the presence of volatile oil, flavonoids, tannins, sterols and/or triterpenes.

Document Type: Article

Language: English

Author Keywords: Marjoram; Origanum majorana; Antiulcer; Antisecretory; Antioxidant




Reprint Address: Rafatullah, S (reprint author), King Saud Univ, Coll Pharm, MAPPRC, POB 2457, Riyadh 11451, Saudi Arabia




E-mail Addresses: srafat@ksu.edu.sa

Funding Acknowledgement:

Funding Agency

Grant Number

College of Pharmacy, Research Center 

CPRC 201 




[Show funding text]   

This work was supported by College of Pharmacy, Research Center (Grant # CPRC 201). The technical assistance of Mr. Malik Sawood Ahmed is thankfully acknowledged.



Publisher: WORLD SCIENTIFIC PUBL CO PTE LTD, 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE

IDS Number: 472IU

ISSN: 0192-415X


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