Status decision of controlled and non-controlled substance(S)




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Health Canada

Santé Canada

1STATUS DECISION OF CONTROLLED

AND NON-CONTROLLED SUBSTANCE(S)

Substance: 2,3-Dihydro-3-hydroxy-2-oxo Lysergide

Based on the current information available to the Office of Controlled Substances, it appears that the above substance is:
Controlled ☐

Not Controlled X

under the schedules of the Controlled Drugs and Substances Act (CDSA) for the following reason(s):



  • 1The substance is 1not a salts of lysergic acid(LSD) and therefore not included under item 5 of Schedule III to the CDSA.

Prepared by: _______________________________________ Date: _______________

Vincent Marleau

Verified by: _______________________________________ Date: ________________

Mark Kozlowski

Approved by: _______________________________________ Date: ________________

DIRECTOR, OFFICE OF CONTROLLED SUBSTANCES


This status was requested by: 1“third party information removed as per agreement with applicant”



Drug Status Report



Drug: 1 2,3-Dihydro-3-hydroxy-2-oxo Lysergide
1Drug Name Status: 1 2,3-Dihydro-3-hydroxy-2-oxo Lysergide is the common name.
Chemical Name:

1(6aR,9R)-N,N-diethyl-5a-hydroxy-7-methyl-5-oxo-4,5,5a,6,6a,7,8,9-octahydroindolo[4,3-fg]quinoline-9-carboxamide


Other Names: N,N-Diethyl-2,3-dihydro-3-hydroxy-2-oxo-lysergamide; (8β)-9,10-Didehydro-N,N-diethyl-2,3-dihydro-3-hydroxy-6-methyl-2-oxoergoline-8-carboxamide; 2-Oxo-3-hydroxy-LSD; 2-Oxo-3-hydroxy Lysergic Acid Diethylamide.
Chemical structure:



Molecular Formula: 1C20H25N3O3

1

Pharmacological class / Application: Lysergic acid metabolite

1

1CAS-RN: 111295-09-1


International status:

US: 1 2,3-Dihydro-3-hydroxy-2-oxo Lysergide is not listed specifically in the Schedules to the US Controlled Substances Act and is not mentioned anywhere on the DEA website.


United Nations: The substance is not listed on the Yellow List - List of Narcotic Drugs under International Control, the Green List - List of Psychotropic Substances under International Control, nor the Red List - List of Precursors and Chemicals Frequently Used in the Illicit Manufacture of Narcotic Drugs and Psychotropic Substances under International Control.

Canadian Status: 11 2,3-Dihydro-3-hydroxy-2-oxo Lysergide is not listed in the Schedules to the CDSA. The 1substance has been reported to be a major metabolite of lysergic acid(LSD), which is currently listed as item 5 of Schedule III to the CDSA, with the heading “Lysergic acid diethylamide (LSD) (N,N–diethyllysergamide) and any salt thereof”. Since 2,3-Dihydro-3-hydroxy-2-oxo Lysergide is1 not a salt of lysergic acid, it cannot be included under item 5 of Schedule III to the CDSA.


Recommendation: 1 2,3-Dihydro-3-hydroxy-2-oxo Lysergide is not included in the schedules to the CDSA and is not a controlled substance.
Date: May 8th, 2012.


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