Status decision of controlled and non-controlled substance(S)




Дата канвертавання25.04.2016
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Health Canada

Santé Canada

1STATUS DECISION OF CONTROLLED

AND NON-CONTROLLED SUBSTANCE(S)

Substance: 11Tricaine methanesulfonate

Based on the current information available to the Office of Controlled Substances, it appears that the above substance is:
Controlled ☐

Not Controlled X

under the schedules of the Controlled Drugs and Substances Act (CDSA) for the following reason(s):



  • 1The substance is not structurally similar to any of those included in the schedules to the CDSA.

Prepared by: _______________________________________ Date: _______________

Vincent Marleau

Verified by: _______________________________________ Date: ________________

Mark Kozlowski

Approved by: _______________________________________ Date: ________________

DIRECTOR, OFFICE OF CONTROLLED SUBSTANCES




This status was requested by: “third party information removed as per agreement with applicant”



Drug Status Report

Drug: 1 Tricaine methanesulfonate
1Drug Name Status: 1 Tricaine methanesulfonate is the common name.
Chemical Name: Ethyl 3-aminobenzoate methanesulfonate
Other Names: MS-22; Metacaine; TS 222; Tricaine-S; TMS; Tricaine mesylate; Ethyl-m-amino-benzoate; m-Aminobenzoic acid ethyl ester methanesulfonate.
Chemical structure:



Molecular Formula: 1C9H11NO2CH4O3S 1CAS-RN: 886-86-2

1

Pharmacological class / Application: Anaesthetic


International status:

US: 1 Tricaine methanesulfonate is not listed specifically in the Schedules to the US Controlled Substances Act and is not mentioned anywhere on the DEA website.


United Nations: The substance is not listed on the Yellow List - List of Narcotic Drugs under International Control, the Green List - List of Psychotropic Substances under International Control, nor the Red List - List of Precursors and Chemicals Frequently Used in the Illicit Manufacture of Narcotic Drugs and Psychotropic Substances under International Control.

Canadian Status: 11 Tricaine methanesulfonate is not listed in the Schedules to the CDSA. 1The substance is a benzocaine derivative1 and a widely used anaesthetic agent for poikilotherms such as fish2. Tricaine methansulfonate is not structurally similar to any of the substances listed in the Schedules to the CDSA.


Recommendation: 1 Tricaine methanesulfonate is not included in the schedules to the CDSA and is not a controlled substance.
Date: July 23rd, 2013.

1 Sladky, K.K.S et al. (2001) Comparative efficacy of tricaine methanesulfonate and clove oil for use as anesthetics in red pacu (Piaractus brachypomus). AJVR; 62(3); 337-342.

2 Wayson, K.A. et al. (1976) Studies on the comparative pharmacology and selective toxicity of tricaine methanesulfonate: metabolism as a basis of the selective toxicity in poikilotherms. J Pharmacol Exp Ther; 198(3): 695-708.


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