The Oxford College of Pharmacy, J.P.Nagar, Ist Phase,
Course of study and subject
Date of Admission
Title of the Topic
PHARMACOGNOSTICAL, PHYTOCHEMICAL AND ANTIMICROBIAL ACTIVITY ON
Jasminum grandiflorum Linn
Brief resume of the intended work:
6.1- Need for the study:
Leaf of Jasminum grandiflorum is also called as Chameli, Chambeli and Mallige belonging to family Oleaceae. It is a plant with fragrant flowers is generally found in all over India, especially in the temperate regions and on the temperate Himalayas(1).
The Chameli leaves contain resin, salicylic acid, jasminine an alkaloid and an astringent principle(2). An Indole oxygenase has been isolated from the leaves(3). Secoiridoid glucosides, 2″-epifraxamoside and demethyl-2″-epifraxamoside, and the secoiridoid, jasminanhydride were isolated from Jasminum grandiflorum Secoiridoid glucosides, 2″-epifraxamoside and demethyl-2″-epifraxamoside, and the secoiridoid, jasminanhydride were isolated from Jasminum grandiflorumSecoiridoid glucosides, 2″-epifraxamoside and demethyl-2″-epifraxamoside, and the secoiridoid, jasminanhydride were isolated from Jasminum grandiflorum Secoiridoid glucosides viz., 2″-epifraxamoside and demethyl-2″-epifraxamoside, jasminanhydride were isolated from Jasminum grandiflorum(4) and the leaves also have reported to contain ascorbic acid, anthranilic acid and its glucoside(5). Terpenoids viz., benzyl acetate, benzyl benzoate, jasmine, linalool and phytol isomers have been reported in the flowers(6), Also Oleacein (ACE inhibitor), 2-(3,4-dihydroxyphenyl)ethanol, isoquercitrin and ursolic acid(7) has been isolated from aerial parts.
The leaves of Jasminum grandiflorum is used in folk medicine for treating ulcerative stomatitis, toothache, skin diseases, ulcers, wounds, corns and also as gargles(9). It has been reported to possess anti ulcer in vitro antioxidant(10), anti-lipid per oxidation (11) and spasmolytic activity(12). Secoiridoid glucosides, 2″-epifraxamoside and demethyl-2″-epifraxamoside, and the secoiridoid, jasminanhydride were isolated from Jasminum grandiflorum
Although very less emphasis has been given to pharmacognostical, phytochemical and pharmacological studies. Therefore it is proposed to study the pharmacognostical properties of leaves of Jasminum grandiflorum, isolation of chemical constituents and antimicrobial activity of extract and isolated compound.
6.2 – Review of Literature:
An alkaloid jasminine, resin and salicylic acid have been reported from the leaves of Chameli(2).
An Indole oxygenase from the leaves of Jasminum grandiflorum(3).
Khare CP. India Medicinal Plants. An Illustrated Dictionary. Springer International Edition New Delhi 2007; 343-344.
Cum G, Spadaro A, Citrara T, Gallo R. Processo di estrazionein fase supercritical da fioridi Jasminum grandiflorum L. Essenze Derivati Agrumari 1998; 68(4): 384-400.
Somanadhan B, Smitt UW, George V, Pushpangadan P, Rajasekharan S, Duus JO, et al. Angiotensin converting enzyme(ACE) inhibitors from Jasminum azoricum and Jasminum grandiflorum. Planta Med 1998; 64(3):246-50.
Khare CP. Encyclopedia of India Medicinal Plants, Rational Western Therapy, Ayurvedic and other traditional Usage. Botany, Springer-Verlag Berlin Heidelberg, New York 2007; 267-68.
Umamaheswari M, Asokkumar K, Rathidevi R, Sivashanmugam AT, Subbhardadevi V, Ravi TK. Anti ulcer and in vitro antioxidant activities of Jasminum grandiflorum L. J Ethnopharmacol 2007; 110(3):464-70.
Kolanjiappan K, Manoharan S. Chemopreventive efficacy and anti-lipid peroxidative potential of Jasminum grandiflorum Linn. On 7,12-dimethylbenz(a)anthracene-induced rat mammary carcinogenesis. Fundam Clin Pharmacol 2005; 19(6):687-93.
Lis-Balchin M, Hart S, Wan Hang Lo B. Jasmine absolute (Jasminum grandiflora L.) and its mode of action on guinea-pig ileum in vitro. Phytother Res 2002; 16(5):437-9.