Fungi causing Subcutaneous Zygomycosis. Zygomycosis (Mucorales)




Дата канвертавання24.04.2016
Памер14.45 Kb.
Fungi causing Subcutaneous Zygomycosis.



  1. Zygomycosis (Mucorales).


Mucorales infections Definition:

  • Angiotropic (blood vessel-invading)

  • The most common genera causing disease are:

    • Rhizopus

    • Rhizomucor

    • Mucor

    • Absidia

  • Fast growing non-septate molds


Geographical distribution & normal habitat


Clinical forms

The infection typically involves the:





Risk factors

  • The disease is associated with:




  • It is also seen in patients with

    • Leukemia

    • Lymphoma

    • AIDS

    • In patients using corticosteroids


Laboratory diagnosis

  • Specimens:

    • Aspirated material from sinuses

    • Sputum in pulmonary disease

    • Biopsy material



Management of mucormycosis


2- Zygomycosis
Order
Entomophthorales

Entomophthorales infections

  • Causes subcutaneous zygomycosis

  • Known as Entomophthoromycosis




  • Tow genera are involved:

    • Conidiobolus

    • Basidiobolus




  • Infections are:

    • Chronic

    • Slowly progressive

    • Restricted to the subcutaneous tissue





Basidiobolus infection

  • Chronic inflammatory or granulomatous disease

  • Subcutaneous tissue of the limbs, chest, back or buttocks

  • Mostly in children (predominance in males)


Conidiobolus infection

  • Chronic inflammatory or granulomatous disease

  • Nasal submucosa

  • Characterized by polyps or palpable subcutaneous masses

  • Occur mainly in adult (80% of cases)



Laboratory diagnosis

  1. Specimens:

    • Aspirated material from sinuses

    • Biopsy material


The following steps are used for the both types of Zygomycosis:

  1. 10 or 20% KOH:

    • Typically contain thick-walled aseptate hyphae

    • Swollen cells (up to 50 um) and distorted hyphae may be present


2- Culture:

    • SDA without cycloheximide at 30°C

    • Rapid growth

3- A diagnosis can also be made by examining a biopsy for granuloma formation and the presence of aseptate hyphae, eosinophils, neutrophils, and fibroblasts. Tissue for culture should be send in a dry sterile container, and biopsies should be fixed and send in formal saline.







База данных защищена авторским правом ©shkola.of.by 2016
звярнуцца да адміністрацыі

    Галоўная старонка