Education and Professional Experience




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Curriculum Vitae

 

 



蔡 勇,医学博士,教授,唐敖庆特聘教授,博士生导师
吉林大学 生命科学学院

中国吉林省长春市前进大街2699号

邮编:130012

电话:0431-87078281

电邮:caiyong62@jlu.edu.cn

 

 



 

Education and Professional Experience:

2009.9-current Professor, The College of Life Science in Jilin University

2001-2009.8   Posdoc-Research Specialist I, Stowers Institute for Medical Research

2000.12-2001   Research Associate, Oklahoma Medical Research Foundation (with R. and J. Conaway)

1998-2000.11   Researcher, Tokyo Medical and Dental University, Japan (with S. Kitajima)

1994-1998          Ph.D., Kyushu University, Japan (with S. Kitajima)

1991-1993     Attending Physician, Yanbian University, China

1988-1991         M.S. in Hematology and Biochemistry, China Medical University, China

1985-1988          Resident Physician, Yanbian University, China 

1980-1985     B.S., Jilin Medical University, China.            

 

 

Academic Honors and Awards



1999                          Excellent Scientific Paper Award, Medical Research Institute of Tokyo Medical and Dental University, Japan

1997-1998          Japan Peace and Friendship Special Scholarship, Japan International Education Society, Japan

1995- 1997    Konan Asia International Scholarship, Konan Asia InternationalScholarship Foundation, Japan

 

Membership in Professional Societies

American Society for Biochemistry and Molecular Biology (since 2003)

 

Publications



 

1.      Zhu, W.G., Aramaki, R., Cai, Y., Antoku, S (1996)  Promotion of heat-induced apoptosis in FM3A cells by protease inhibitor. Biochemical and Biophysical Research Communications, 225, 924-31.

2.      Cai, Y., Kitajima S., Etoh F., Kinoshita, S., Okubo, K., Hamasaki, N (1997) Autoantibody reactive with the human general transcription factor TFIIF in sera from patient with autoimmune disorders. Clinical and Experimental Immunology, 109, 488-94.

3.      Cai, Y., Mitsuyasu, M., Zhang, C., Hamasaki, N., Kitajima, S (1998)  Structure of human transcription factor TFIIF revealed by limited proteolysis with trypsin. FEBS Letters, 43, 191-4.

4.      Satoru Oshiro, Masahiro Kawahara, Shirao Mika, Kazuyo Muramoto, Kazuo Kobayashi, Ryuta Ishige, Koji Nozawa, Makoto Hori, Yong Cai, Shigetaka Kitajima, and Yoichiro Kuroda (1998)  Aluminum taken up by transferrin-independent iron uptake affects the iron metabolism in rat cortical cells. Journal of Biochemistry, 123, 42-6.

5.      Oshiro S., Nozawa, K., Cai,Y ., Hori, M., Kitajima, S (1998)  Characterization of a transferrin-independent iron uptake system in rat primary cultured cortical cells. Journal of Medical and Dental Sciences, 45, 171-6.

6.      Shigetaka Kitajima, Yong Cai, Chun Zhang, Makiko Tanaka, Tigre Nawa and Satoru Oshiro (1998) Mechanism of transcription by RNA polymerase II. – Molecular basis of regulated gene expression-. Journal of Medical and Dental Sciences, 45,59-67.

7.      Shigetaka Kitajima, Yong Cai, Makiko Tanaka, Tigre Nawa, Satoru Oshiro (1998) Transcription factor and disease. Clinical Chemistry,  27, 252-58.

8.      Hayakawa, H., Hofer, A., Thelander, L., Kitajima, S., Cai, Y., Oshiro, S., Yakushiji, H., Nakabeppu, Y., Kuwano, M., Sekiguchi, M (1999) Metabolic fate of oxidized guanine ribonucleotides in mammalian cells. Biochemistry, 38, 3610-14.

9.      Nawa, T., Nawa, M.T., Cai, Y., Zhang, C., Uchimura, I., Narumi, S., Namano, F., Kitajima , S ( 2000) Repression of TNF-alpha-induced E-selectin expression by PPAR activators: involvement of transcriptional repressor LRF-1/ATF3. Biochemical and Biophysical Research Communications, 225, 406-11.

10.    Cai, Y., Zhang, C., Nawa, T., Aso, T., Tanaka, M., Oshiro, S., Ichijo, H., Kitajima, S (2000) Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: activation of c-Jun NH2-terminal kinase and promoter response element. Blood, 96, 2140-8.

11.    Oshiro, S., Kawahara, M., Kuroda, Y., Zhang, C., Cai, Y., Kitajima, S., Shirao, M (2000) Glial cells contribute more to iron and accumulation but are more resisiant to oxidative stress than neuronal cells. Biochemica et Biophysica Acta, 1502, 405-14.

12.    Zhang, C., Cai, Y., Adachi, MT., Oshiro, S., Aso, T., Kaufman, RJ., Kitajima, S (2001) Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response. Journal of Biological Chemistry, 276, 35867-74.

13.    Sato, S., Tomomori-Sato, C., Banks, C.A., Sorokina, I., Parmely, T.J., Kong, S.E., Jin, J., Cai, Y., Lane, W.S., Brower, C.S., Conaway, R.C., Conaway, J.W. (2003) Identification of mammalian mediator subunits with similarities to yeast mediator subunits Srb5, Srb6, Med11, and Rox3. Journal of Biological Chemistry, 278, 15123-27.

14.    Cai, Y., Jin, J., Tomomori-Sato, C., Sato, S., Sorokin, I., Parmely, TJ., Conaway, RC. and Conaway, JW (2003)  Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. Journal of Biological Chemistry, 278, 42733-6. (co-first author)

15.    Sato, S., Tomomori-Sato, C., Parmely, T.J., Florens, L., Zybailov, B., Swanson, S.K., Banks, C.A., Jin, J., Cai, Y., Washburn, M.P., Conaway, J.W. and Conaway, R.C. (2004) A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. Molecular Cell, 14, 685-91.

16.    Yan, Q., Kamura, T., Cai, Y., Jin, J., Ivan, M., Mushegian, A., Conaway, R.C. and Conaway, J.W. (2004)  Identification of elongin C and Skp1 sequences that determine cullin selection. Journal of Biological Chemistry, 279, 43019-26.

17.    Cai, Y., Jin, J., Florens, L., Swanson, SK., Kusch, T., Li, B., Workman, JL., Washburn, MP., Conaway, RC., and Conaway, JW (2005)  The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. Journal of Biological Chemistry, 280, 13665-70. (co-first author)

18.    Jin, J., Cai, Y., Yao, T., Gottschalk, A., Florence, F., Swanson, SK., Gutierrez, J., Coleman, MK., Workman, JL., Mushegian, A., Washburn, MP., Conaway, RC and Conaway, JW (2005) A mammalian chromatin remodeling complex with similarities to the yeast Ino80 complex. Journal of Biological Chemistry, 280, 41207-12. (co-first author)

19.    Jin, J., Cai, Y., Li, B., Conaway, RC., Conaway, JW., Workman, JL. and Kusch, T (2005)  In and out: Histone variant exchange in chromatin. Trends in Biochemical Sciences, 30, 680-87.

20.    Yong Cai, Jingji Jin, Aaron J. Gottschalk, Tingting Yao, Joan W. Conaway and Ronald C. Conaway (2006) Purification and assay of the human INO80 and SRCAP chromatin remodeling complexes. Methods, 40, 312-17.

21.    Donald D. Ruhl, Jingji Jin, Yong Cai, Selene Swanson, Laurence Florens, Michael P. Washburn, Ronald C. Conaway, Joan W. Conaway and John C. Chrivia (2006) Purification of human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes. Biochemistry, 45, 5671-77.

22.    Cai, Y., Jin, J., Yao, T., Gottschalk, A.J., Swanson, S.K., Wu, S., Shi, Y., Washburn, M.P., Florens, L., Conaway, R.C., and Conaway, J.W. (2007) YY1 functions with INO80 to activate transcription. Nature Structural & Molecular Biology, 14, 872 – 74. (co-first author)

23.    Sardiu, M.E., Cai, Y., Jin, J., Swanson, S.K., Conaway, R.C., Conaway J.W., Florens, L., and Washburn, M.P.. (2008) Probabilistic assembly of human protein interaction networks from label-free quantitative proteomics. Proceedings of the National Academy of Sciences,  105, 1454–59.

24.    Yao, T., Song, L., Jin, J., Cai, Y., Takahashi, H., Swanson, S.K., Washburn, M.P., Florens, L., Conaway, R.C., Cohen, R.E., and Conaway, J.W. (2008) Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin remodeling complex. Molecular Cell, 31, 909-17.

  1. Gottschalk AJ, Timinszky G, Kong SE, Jin J, Cai Y, Swanson SK, Washburn MP,

Florens L, Ladurner AG, Conaway JW, Conaway RC. (2009) Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler. Proc Natl Acad Sci U S A. 18;106(33):13770-4.

  1. Cai Y, Jin J, Swanson SK, Cole MD, Choi SH, Florens L, Washburn MP, Conaway

JW, Conaway RC. (2010) Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal(MSL) complex. J Biol Chem. 12;285(7):4268-72.



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