Curriculum Vitae Name

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Curriculum Vitae

Name: Steven C. Ley

Address: Division of Immune Cell Biology

MRC National Institute for Medical Research

Mill Hill



1982-1987 Ph.D. (Immunology)

University of Cambridge

1979-1982 B.Sc. (Biochemistry)

University of Bristol

Current Appointment
1992 - Staff Scientist

MRC National Institute for Medical Research, Mill Hill, London.

2013 - Professor of Molecular Immunology

Department of Medicine

Imperial College London

Previous Employment

1990 - 1992 ICRF Post-doctoral Fellow

Cell Surface Biochemistry Laboratory, ICRF, London

(With Dr. Mike Crumpton)

1987 - 1990 NATO Post-doctoral Fellow

Dana-Farber Cancer Institute, Boston, MA 02115, USA.

(With Dr. Cox Terhorst)

Current research Interests
Regulation and function of the TPL-2 / ABIN-2 / NF-B1 P105 complex in immunity
Lab web page

Selected publications

  1. Mitogen-activated protein kinases in innate immunity. (2013) Arthur, J. S. & Ley, S. C. Nature Rev. Immunol, 13: 679 – 692.

  1. McNab, F. W., Ewbank, J., Rajsbaum, R. Stavropoulos, E., Martirosyan, A., Redford, P. S., Wu, X., Graham, C. M., Saraiva, M. Tsichlis, P., Chaussabel, D., Ley, S. C. & O’Garra, A. (2013) TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I IFN production. J. Immunol. 191: 1732 – 1743.

  1. Gantke, T., Boussouf, S., Janzen, J., Morrice, N., Howell, S., Mühlberger, E. & Ley, S. C. (2013) Ebola virus VP35 induces high-level production of recombinant TPL-2/ABIN-2/NF-κB1 p105 complex in co-transfected HEK-293 cells. Biochem. J. 452: 359 – 365.

  1. Roget, K., Ben-Addi, A., Mambole-Dema, A., Gantke, T., Janzen, J., Yang, H.-T., Shpiro, N., Morrice, N., Abbott, D. and Ley, S. C. (2012) IKK2 regulates TPL-2 activation of ERK-1/2 MAP kinases by direct phosphorylation of TPL-2 serine 400. Mol. Cell. Biol. 32: 4684 – 4690.

  1. Yang, H.T., Papoutsopoulou, M., Belich, M.P., Brender, C., Janzen, J., Gantke, T., Handley, M. and Ley, S.C. (2012) Coordinate regulation of TPL-2 and NF-κB signaling in macrophages by NF-B1 p105. Mol. Cell. Biol. 32: 3438 – 3451.

  1. Gantke, T., Sriskantharajah, S. and Ley, S. C. (2012) IκB kinase regulation of the TPL-2 / ERK MAP kinase pathway. Immunol. Rev. 246: 168 – 182.

  1. Yang, H.-T., Wang, Y., Zhao X., Demissie, E., Papoutsopoulou S., O’Garra, A., Tomczak, M. F., Erdman, S. E., Fox, J. G., Ley, S. C. * and Horwitz, B.* (2011) NF-κB1 inhibits TLR-induced IFN-production in macrophages through TPL-2-dependent ERK activation. J. Immunol. 186: 1989-1996.

(* Co-corresponding authors)

  1. Gantke, T., Sriskantharajah, S. and Ley, S. C. (2010) Regulation and function of TPL-2, an IKK-regulated MAP kinase kinase kinase. Cell Research. 21:131-45.

  1. Sriskantharajah, S. and Ley, S. C. (2010) Turning off inflammation signalling. Science. 327: 1093 – 1094.

  1. Kaiser, F., Cook, D., Papoutsopoulou, S., Rajsbaum, R., Wu, X., Yang, H.-T., Grant, S., Ricciardi-Castagnoli, P., Tsichlis, P. N., Ley, S. C*. and O’Garra, A.* (2009) TPL-2 negatively regulates interferon- production in macrophages and myeloid dendritic cells. J. Exp. Med. 206:1863 – 71.

(* Co-corresponding author)

  1. Jacques, E. and Ley, S. C. (2009) RNF11: a new piece in the A20 puzzle. EMBO J. 28: 455 – 456.

  1. Sriskantharajah, S., Belich, M. P., Papoutsopoulou, S., Janzen, J., Tybulewicz, V., Seddon, B. and Ley, S. C. (2009) NF-κB1 p105 proteolysis is essential for T cell receptor-induced proliferation. Nature Immunol. 10: 38 - 47.

  1. Sun, S.-C. and Ley, S. C. (2008) New insights into NF-κB regulation and function. Trends Immunol. 29: 469 - 478.

  1. Rousseau, S., Papoutsopoulou, S., Symons, A., Cook, D., Lucocq, J. M., Prescott, A. R., O’Garra, A., Ley, S. C. and Cohen, P. (2007) Tpl-2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF in LPS-stimulated macrophages. (2008) J. Cell Sci. 121: 149-154.

  1. Robinson, M. J., Beinke, S., Kouroumalis, A., Tsichlis, P. N. and Ley, S. C. (2007) Phosphorylation of TPL-2 on serine 400 is essential for LPS activation of ERK in macrophages. Mol. Cell. Biol. 27: 7355-7364.

  1. Papoutsopoulou, S., Symons, A., Tharmalingham, T., Belich, M. P., Kaiser, F., Kioussis, D., O’Garra, A., Tybulewicz, V. and Ley, S. C. (2006) ABIN-2 is required for optimal activation of the TPL-2 / ERK MAP kinase pathway in innate immune responses. Nature Immunol. 7: 606-615.

  1. Symons, A., Beinke, S., Ley, S. C. (2006) MAP kinase kinase kinases and innate immunity. Trends Immunol. 27:40-48.

  1. Beinke, S. and Ley, S. C. (2004) Functions of NF-κB1 and NF-κB2 in immune cell biology. Biochem. J. 382, 393-409.

  1. Beinke, S., Robinson, M., Salmeron, A., Hugunin, M., Allen, H. and Ley, S. C. (2004) Lipopolysaccharide activation of the TPL-2 / MEK / ERK MAP kinase cascade is regulated by IKK-induced proteolysis of NF-κB1 p105. Mol. Cell. Biol. 24, 9658-9667.

  1. Lang, V., Symons, A., Watton, S. J., Janzen, J., Beinke, S., Soneji, Y., Howell, S. and Ley, S. C. (2004) ABIN2 forms a ternary complex with TPL-2 and NF-κB1 p105 and is essential for TPL-2 stability. Mol. Cell. Biol. 24, 5235-5248.

  1. Atkinson, P., Coope, H. J., Rowe, M. and Ley, S. C. (2003) Latent membrane protein 1 of Epstein-Barr virus stimulates processing of NF-κB2 p100 to p52. J. Biol. Chem. 278, 51134-51142.

  1. Beinke, S., Deka, J., Lang, V., Belich, M. P., Walker, P. A., Howell, S., Smerdon, S. J., Gamblin, S. J. and Ley, S. C. (2003) NF-κB1 p105 negatively regulates TPL-2 MEK kinase activity. Mol. Cell. Biol. 23, 4739-4752.

  1. Lang, V., Janzen, J., Fischer, G. Z., Soneji, Y., Beinke, S., Salmeron, A. Allen, H., Hay, R. T., Ben-Neriah, Y. and Ley, S. C. (2003) TrCP-mediated proteolysis of NF-κB1 p105 requires phosphorylation of p105 serines 927 and 932. Mol. Cell. Biol. 23, 402-413.

  1. Coope, H. J., Atkinson, P. G. P., Huhse, B., Belich, M., Janzen, J., Holman, M. J., Klaus, G. G. B., Johnston, L. H. and Ley S. C. (2002) CD40 regulates the processing of NF-κB2 p100 to p52. EMBO J. 21, 5375-5385.

  1. Beinke, S., Belich, M. P. and Ley S. C. (2002) The death domain of NF-κB1 p105 is essential for signal-induced p105 proteolysis. J. Biol. Chem., 277, 24162-24168.

  1. Salmeron, A., Janzen, J., Soneji, Y., Bump, N., Kamens, J., Allen, H. and Ley, S. C. (2001) Direct phosphorylation of NF-κB1 p105 by the IκB kinase complex on serine 927 is essential for signal-induced p105 proteolysis. J. Biol. Chem., 276, 22215-22222.

  1. Belich, M. P., Salmeron, A., Johnston, L. H. and Ley, S. C. (1999) TPL-2 kinase regulates the proteolysis of the NF-κB inhibitory protein NF-κB1 p105. Nature, 397, 363-368.

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