Curriculum vitae degeng Wang, Phd contact Information

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Degeng Wang, PhD
Contact Information


San Diego Supercomputer Center

University of California, San Diego

La Jolla, CA 92093-0505

Tel:(858)822-3616 Fax:(858)822-3610



12661 Portada Place

San Diego, CA 92130


Professional Experiences:
07/2003-Present: Assistant Scientist

09/2000-06/2003: Senior Postdoctoral Researcher

San Diego Supercomputer Center, University of California at San Diego

*Computational systems biology: Developed hierarchical clustering program to combine maximal and average linkage approaches; Comparative kinomics analysis using the developed program; Database and web interface design for functional genomics; Data integration for proteomic projects.

06/1998-08/2000: Postdoctoral Research Associate

HHMI, University of California, San Diego

*Signal transduction: Studied mechanisms by which CBP/p300 integrates multiple signaling pathways to specify transcription regulation events.

09/1993-01/1998: Graduate research assistant, Medical College of Ohio.

*Cancer biology: Studied aberrant TGFα and EGF receptor expression in tumor cells and the role of this aberrancy in tumor progression; Studied crosstalks between IGF receptor and EGF receptor signaling in cell growth regulation.
Ph.D., 09/1992-02/1998. Medical College of Ohio.

Area of concentration: Cancer Biology.

09/1999 – 08/2003. (Part-time M.S. Student*) San Diego State University

Area of concentration: Computer Science *Not pursuing the degree

B.S., 09/1986-09/1991. University of Science and Technology of China (USTC).

Major in biological sciences.

Awards and Scholarships
10/2005-09/2007: UCSD PI on funded grant (NIH-R21-AR052863-01)

PI: Bogi Andersen, MD, UC Irvine.

09/1992-09/1996: Pre-doctoral Fellowship, Medical College of Ohio.

Scientific Societies

  • American Association for the Advancement of Science (AAAS)

  • International Society of Computational Biology (ISCB)

  • American Association for Cancer Research (AACR)

Specific Expertise



--C, C++, JAVA, PERL Programming

--Enzyme structure-function relationship

--Database management

--Western blot and immunoprecipitation

--Database search and sequence analysis

--Silver staining

--Biological modeling

--Enzyme linked immunosorbent assay

Tissue Culture and Cell Biology:

Molecular Biology:

--Media composition and preparation

--Site-directed mutagenesis

--Routine maintenance of cell lines

--In vitro transcription and probe labeling

--Mitogenesis assays

--RNA isolation and RNase protection assay

--Metabolic labeling with 35S or 32P

--cDNA library construction and screening

--Cell surface receptor analysis

--Polymerase chain reaction (PCR)

--Transient and stable transfection

--Promoter activity assays

Invited Bioinformatics Lecture
11/2003: "Comparative Genomics of Protein Kinases". Bioinformatics Forum, UC Irvine.
Publications and Abstracts
Degeng Wang and Michael Gribskov. Evolutionary study of S. cerevisiae transcription network. Manuscript in preparation, 2005.

Degeng Wang and Michael Gribskov. Comparative kinomics of yeast, plant, and animal. Manuscript in preparation, 2005.

Degeng Wang* and Michael Gribskov. Examining the Architecture of Cellular Computing through a Comparative Study with a Computer. Journal of the Royal Society Interface 2(3)#: 187-195, 2005. * Corresponding author; # A new journal by the Royal Society in London ( to interface between the physical and life sciences.

Degeng Wang. “Molecular gene”: Interpretation in the right context. Biology and Philosophy 20(2-3): 453-464, 2005.

Degeng Wang*, Jeffrey F. Harper, and Michael Gribskov. Systematic trans-genomic comparison of protein kinases between Arabidopsis and Saccharomyces cerevisiae. Plant Physiology 132: 2152-2165, 2003. * Corresponding author

Sung Hee Baek, Chrissa Kioussi, Paola Briata, Degeng Wang, H. D. Nguyen, Kenneth A. Ohgi, Christopher K. Glass, Anthony Wynshaw-Boris, David W. Rose, and Michael G. Rosenfeld. Regulated subset of G1 growth-control genes in response to derepression by the Wnt pathway. Proc. Natl. Acad. Sci. USA, 100(6), 3245-3250, 2003.

Jason Tchieu, Fariba Fana, J. Lynn Fink, Jeffrey Harper, Murlidharan Nair, Douglas W. Smith, Ken Steube, Tobey Tam, Stella Veretnik, Degeng Wang, and Michael Gribskov. The PlantsP and PlantsT Functional Genomics Databases. Nucleic Acid Research 31(1): 342-344, 2003.

Degeng Wang, Sandip Patil, Wenhui Li , Elizabeth E. Humphrey, Michael G. Brattain, and Gillian M. Howell. Activation of the TGF-alpha autocrine loop is downstream of IGF-I receptor activation during mitogenesis in growth factor dependent human colon carcinoma cells. Oncogene 21(18): 2785-2796, 2002.

Degeng Wang, Wenhui Li, Wen Jiang, Lisa E. Humphrey, Gillian M. Howell and Michael G. Brattain. Autocrine TGF Expression in the Regulation of Initiation of Human Colon Carcinoma Growth. Journal of Cellular Physiology 177 (3): 387-395, 1998.

Gillian M. Howell, Lisa E. Humphrey, Rana Awad, Degeng Wang, Alan Koterba, Basker Periyasami et al. Aberrant Expression of Autocrine TGF in a Highly Progressed Human Colon Carcinoma Cell Line at a Quiescent State. Journal of Biological chemistry 273 (15): 9214-9223, 1998.

Dianhua Jiang, Haisu Yang, James K.V. Willson, Jiurong Liang, Lisa E. Humphrey, Elizabeth Zborowska, Degeng Wang, Jason Foster, Robert Fan, and Michael G. Brattain. Autocrine Transforming Growth Factor alpha Provides a Growth Advantage to Malignant Cells by Facilitating Re-entry into the Cell Cycle from Suboptimal Growth States. Journal of Biological Chemistry 273 (47): 31471-31479, 1998.

Degeng Wang. The mechanism of Deacetylation of Lef/TCF Transcription Factor upon Activation of Wnt Signaling Pathway. Proceeding of Annual Meeting of American Association for Cancer Research 42:A4807, 2001.

Degeng Wang and Michael G. Brattain. Induction of Autocrine TGF Expression and EGF Receptor Activation in early G1 are Critical for S-Phase Entry in FET Human Colon Carcinoma Cells at a Quiescent State. Proceeding of Annual Meeting of American Association for Cancer Research 38:A2330, 1997.

Degeng Wang, Gillian Howell, Lisa E. Humphrey, Junhua Yang, Jiurong Liang and Michael G. Brattain. Growth Related Expression of TGF alpha in FET Human Colon Carcinoma Cells. Proceeding of Annual Meeting of American Association for Cancer Research 36:A3085, 1995.

Degeng Wang, Gillian Howell, Lisa Humphrey, Junhua Yang and Michael G. Brattain. Transcriptional Control of Autocrine Transforming Growth Factor alpha (TGF) in Colon Carcinoma Cells. Proceeding of Annual Meeting of American Association for Cancer Research 35:A3370, 1994.

Available upon request

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