Curriculum vitae dale e. Mais, Ph. D




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CURRICULUM VITAE
DALE E. MAIS, Ph.D.
BIRTHDATE: March 24, 1952
MARITAL STATUS: Married - May 8, 1976
NUMBER OF CHILDREN: Two
EDUCATION:
Indiana University, Bloomington, IN Ph.D. July 1983

Major: Pharmacology

Minor: Biochemistry
Indiana University, Bloomington, IN M.S. August 1977

Major: Organic Chemistry

Minor: Biochemistry
Indiana University, Bloomington, IN B.S. August 1974

Major: Chemistry

Minor: Mathematics
POSITIONS:
INDIANA UNIVERSITY, BLOOMINGTON, INDIANA

Department of Chemistry

Undergraduate Research Assistant 1972-1974

Teaching Assistant in Chemistry 1973-1977

Graduate Research Assistant 1974-1977
LAFAYETTE PHARMACAL INC., LAFAYETTE, INDIANA

Manager Organic Synthesis 1977-1979


INDIANA UNIVERSITY, BLOOMINGTON, INDIANA

Department of Pharmacology

Teaching Assistant in Anatomy 1979-1980

Graduate Research Assistant, Dept

Of Astronomy 1979-1983
MEDICAL UNIVERSITY OF SOUTH CAROLINA,

CHARLESTON, SOUTH CAROLINA

Postdoctoral Fellow 1983-1986

Assistant Professor 1986-1989


ELI LILLY AND COMPANY, INDIANAPOLIS, INDIANA

Department of Cardiovascular Pharmacology

Senior Pharmacologist 1989-1992

INDIANA UNIVERSITY SCHOOL OF MEDICINE

Indianapolis, IN

Department of Pharmacology and Toxicology

Adjunct Associate Professor 1990-1992
EXPERT ANALYST FOR ORGANIC CHEMISTRY EDITION OF

CHEMTRACTS 1990-1993


LIGAND PHARMACEUTICALS, INC.

Senior Research Scientist 1992-1998

Research Investigator 1998-present
PALOMAR COLLEGE, SAN MARCOS CAMPUS

Department of Earth Sciences

Adjunct Professor of Astronomy 2002-present
PROFESSIONAL AFFILIATIONS:
ASPET

American Chemical Society: Division of Organic and Medicinal Chemistry

American Astronomical Society

Sigma Xi Society

South Carolina Academy of Sciences
HONORS AND AWARDS:
Graduated with Honors: Department of Chemistry, Indiana University, 1974

Ira E. Lee Scholar: Department of Chemistry, Indiana University, 1974

Graduate Grant-In-Aid Recipient, Indiana University, 1982 and 1983

Nation Research Service Award, 1983-1986: HLO7260, March 30, 1986

Drug Science Foundation Scholar, 1983-1986

First Place in Postdoctoral Division of Student Research Day Competition,

Medical University of South Carolina, 1984 and 1985

Louis N. Katz Basic Research Award - Finalist 1985

Listed in American Men and Women of Science, 1991-Present

Who's Who in the West, 1994-Present

Who's Who in Medicine and HealthCare, 1996-Present

Honored Member, Strathmore’s Who’s Who Registry, 1998-.


United Nations Development Program in China-Guest lecturer at the Chinese Academy of Medical Sciences September 7-21, 1997, Beijing PRC

Chinese Academy of Medical Sciences, Guest Lecturer, October 1999, Beijing PRC.

Chinese Academy of Medical Sciences, Guest Lecturer, March 2002, Shanghai PRC.

Chinese Academy of Medical Sciences, Guest Speaker at International Conference on Traditional Chinese Medicines, November, 2002, Chengdu PRC



PATENTS:
Eller, T., Mais, D., Knapp, D. and Halushka, P., Aromatic Derivatives of Pinane Thromboxane A2 and 13-Azaprostanoic Acid. Issued, 1987.
Halushka, P.V., Spicer, K.M. and Mais, D.E., Platelet Receptor Antagonists useful in Detecting Intravascular Platelet Aggregation. Issued Aug. 2, 1994. #5,334,369
Boehm, M., Zhang, L., Badea, B.S., White, S., Mais, D., Berger, E.,Suto C., Goldman, M. and Heyman, R., Synthesis and structure activity relationships of novel retinoid X receptor selective retinoids. Patent filed in USA, published in Europe(WO93/21146 on 10/28/93, PCT US93/03944) 1994
Jakubowski, J., Mais, D.E. and Takeuchi, J. Carbamoyl Substituted Heterocycles. 1998, U.S. Patent #5849766
Jakubowski, J., Mais, D.E. and Takeuchi, J. Carbamoyl Substituted Heterocycles. 2000, U.S. Patent #6075147


BIBLIOGRAPHY:
1. Campaigne, E. and Mais, D.E., 1974, A New Synthesis of Ylidenemalononitriles. Synthetic Comm., 4(6), 379-388.
2. Mais, D.E., The Synthesis and Cyclization of Ylidenemalononitriles to Indenones and Coumarins. B.S. Thesis, Indiana University, 1974
3. Campaigne, E. and Mais, D.E., 1975, Cyclization of Ylidenemalononitriles. VIII. Synthesis of Coumarins from O-Methoxybenzylidenemalononitriles. J. Hetero. Chem., 12, 267.
4. Campaigne, E., Homfeld, E. and Mais, D.E., 1978 Benzo(b)thiophene Derivatives. XXIII. Derivatives of 5,6-Dihydroxy-3-benzo(b)thienylacetic Acid. J. Hetero. Chem., 15, 1351.
5. Mais, D.E., The Synthesis of Some 5,6-Disubstituted Sulfur Analogs of Tryptamine, Melatomin and Harmaline. M.S. Thesis, Indiana University, 1977.
6. Mais, D.E. and Bosin, T., 1981, Structural Specificity of the Inhibition of Serotonin Accumulation in Rat Lung Slices. Res. Comm. Chem. Pathol. Pharmacol., 34, 241.
7. Mais, D.E., Lahr, P. and Bosin, T., 1981, Determination of Serotonin, its Precursors, and Tritiated Serotonin in Lung by High-Pressure Liquid Chromatography with Fluorescence Detection. J. Chromatogr. Biomed. Appl., 225, 27-35.
8. Mais, D.E., Lahr, P. and Bosin, T., 1982, Oxygen-Induced Lung Toxicity: Effect on Serotonin Disposition and Metabolism. Toxicol. Appl. Pharmacol., 64, 221-229.


  1. Mais, D.E., Lahr, P. and Bosin, T., 1982, Effect of Hyperoxia on Serotonin Disposition and Metabolism in Lung. The Pharmacologist, 24(3), 201.

10. Lahr, P., Mais, D.E. and Bosin, T., 1983, Reparative Changes Following Oxygen-Induced Lung Injury: Effect on Serotonin Disposition and Metabolism. Toxicol. Appl. Pharmacol., 70, 188-194.


11. Campaigne, E. and Mais, D.E., 1978, Ethyl 5,6-Dimethoxy-3-Benzo(b)-thienylacetate. J. Hetero. Chem., 15, 1678.
12. Mais, D.E., Lahr, P. and Bosin, T., 1984, Hyperoxia and Paraquat Alter the Kinetics of Platelet Serotonin Uptake. Toxicol. Appl. Pharmacol., 76, 1-8.
13. Mais, D.E. and Bosin, T., 1984, Hyperoxia Alters Platelet Disposition of Serotonin. Toxicol. Letters, 22, 255-259.
14. Mais, D.E. and Bosin, T., 1984, A Role for Serotonin in Alpha-Naphthylthiourea-Induced Pulmonary Edema. Toxicol. Appl. Pharmacol., 74, 185-194.
15. Mais. D.E.: The Role of Serotonin in Pulmonary Microvascular Injury. Ph.D. Thesis, Indiana University, 1983.
16. Halushka, P., MacDermot, J., Knapp, D., Eller, T., Saussy, D., Mais, D.E., Dollery, C. and Blair, I., 1985, A Novel Approach for the Study of Thromboxane Receptors using 125I-Labelled Ligand. Biochem. Pharm. 34, 1165-1170.
17. Mais, D.E., Knapp, D., Ballard, K., Halushka, P. and Hamanaka, N., 1984, Synthesis of Thromboxane Receptor Antagonists with the Potential to Radiolabel with 125I. Tet. Letters 25, 4207-4210.
18. Mais, D.E. and Bosin, T., 1983, Altered Pulmonary Serotonin (5-HT) Disposition and Metabolism with Alpha-Naphthylthiourea. Fed. Proc., 42, 594.
19. Mais, D., Saussy, D., Chaikhouni,M.A., Kochel, P., Knapp, D., Hamanaka, N. and Halushka, P., 1985, Pharmacologic Characterization of Human and Canine Thromboxane A2/Prostaglandin H2 Receptors in Platelets and Blood Vessels: Evidence for Different Receptors. J. Pharmacol. Exp. Ther., 233, 418-424.
20. Saussy, D., Mais, D.E., Knapp, D. and Halushka, P., 1985, Prostaglandin Exdoperoxide and Thromboxane A2 Receptors in Platelets and Vascular Smooth Muscle. Circulation, 72, 1202-1207.
21. Mais, D.E., Dunlap, C., Hamanaka, N. and Halushka, P., 1985, Further Studies on the Effects of Epimers of Thromboxane A2 Antagonists on Platelets and Veins. Eur. J. Pharmacol., 111, 125-128.
22. Saussy, D., Mais, D.E., Burch, R. and Halushka, P., 1986, Identification of a Putative TXA2/PGH2 Receptor in Human Platelet Membranes. J. Bio. Chem., 261, 3025-3029.
23. Mais, D.E., Burch, R., Saussy, D., Kochel, P. and Halushka, P., 1985, Binding of an 125I-labelled Thromboxane A2/Prostaglandin H2 Receptor Antagonist to Washed Human Platelets. J. Pharmacol. Exp. Therap., 239, 729-734.
24. Mais, D.E., Burch, R., Saussy, D., Kochel, P. and Halushka, P., 1985, Binding of an 125I-Labelled Thromboxane A2/Prostaglandin H2 Receptor Antagonist to Washed Human Platelets. J. Pharmacol. Exp. Therap., 239, 729-734.
25. Burch, R., Mais, D.E., Saussy, D. and Halushka, P., 1985, Solubilization of a Thromboxane A2/Prostaglandin H2 Antagonists Binding Site from Human Platelets. Proc. Natl. Acad. Sci., USA., 82, 7434-7438.
26. Burch R., Mais, D.E., Pepkowitz, S. and Halushka, P., 1985, Binding Site Solubilized from Human Platelets. Biochem. Biophy. Res. Comm., 132, 961-968.
27. Mais, D.E., Burch, R., Oatis, J., Knapp, D. and Halushka, P., 1986, Photo-affinity Labelling of a Thromboxane A2/Prostaglandin H2 Antagonist Binding Site in Human Platelets. Biochem. Biophy. Res. Comm., 140, 128-133.
28. Burch, R., Luini, A., Mais, D.E., Corda, D., Vanderhock, J., Kohn, L. and Axelrod, J., 1986, -Adrenergic Stimulation of Arachidonic Acid Release and Metabolism in a Rat Thyroid Cell Line. Mediation of Cell Replication by Prostaglandin E2. J. Biol. Chem., 261, 11236-11241.
29. Halushka, P., Mais, D.E. and Garvin, M., 1986, Binding of a Thromboxane A2/Prostaglandin H2 Receptor Antagonist to Guinea Pig Platelets. Eur. J. Pharm., 131, 49-54.
30. Bosin, T.R., Krough, S. and Mais, D.E., 1986, Identification and Quantitation of 1,2,3,4-Tetrahydro--carboline-3-carboxylic Acid and 1-Methyl-1,2,3,4-tetrahydro--carboline-3-carboxylic acid in Beer and Wine. J. Agric. Food Chem., 34, 843-847.
31. Hubbard, H.L., Eller, T.D., Mais, D.E., Halushka, P.V., Baker, R.H., Blair, I.A., Vrbanac, J.J. and Knapp, D.R., 1987, Extraction of Thromboxane B2 from Urine Using an Immobilized Antibody Column for Subsequent Analysis by Gas Chromatography-Mass Spectrometry. Prostaglandins, 33, 149-161.
32. Dorn, G.W. II, Burch, R.M., Kochel, P.J., Mais, D.E. and Halushka, P.V., 1987, Decrease in Agonist Affinity to Human Platelet Thromboxane A2/Prostaglandin H2 Receptors Induced by a Platelet Derived Protein. Biochemical Pharmacology, 36, 1913-1917.
33 Halushka, P.V., Mais, D.E. and Kochel, P.J., 1987, Binding of Thromboxane A2/Prostaglandin H2 Agonists to Human Platelets. Br. J. Pharmacol., 91, 223-227.
34. Dorn, G.W. II, Sens, D., Chaikhouni, A., Mais, D.E. and Halushka, P.V., 1987, Cultured Human Vascular Smooth Muscle Cells with Functional Thromboxane A2/Prostaglandin H2 Agonists to Human Platelets. Br. J. Pharmacol., 60, 952-956.
35. Liel, N., Mais, D.E. and Halushka, P.V., 1987, Binding of the Thromboxane A2/Prostaglandin H2 Agonist [3H]-U46619 to Washed Human Platelets. Prostaglandins, 33, 789-797.
36. Halushka, P., Mais, D.E. and Saussy, D., 1987, Platelet and Vascular Smooth Muscle Thromboxane A2/Prostaglandin H2 Receptors. Fed.Proc., 46, 149-153.
37. Saussy, D.L., Jr., Mais, D.E., Baron, D.A., Pepkowitz, S.H. and Halushka, P.V., 1988, Subcellular Localization of a Thromboxane A2/Prostaglandin H2 Receptor Antagonist Binding Site in Human Platelets. Biochemical Pharmacology, 37, 647-654.

38. Halushka, P., Mais, D.E. and Saussy, D., 1988, Characterization of Thromboxane A2/Prostaglandin H2 Receptors: in Proceedings of the 5th Annual Smith Kline and French Symposium: Cellular and Molecular Aspects of Inflammation. Eds. Crooke, S. and Poste, G., 335-354.


39. Mais, D.E., DeHoll, D., Sightler, H. and Halushka, P.V., 1988, Structure Activity Relationships for 13-Azapinane Thromboxane A2 Analogs in Platelets and Blood Vessels. European J. Pharmacol., 147, 309-316.
40. Mais, D.E. and Halushka, P., 1988, Synthesis of an [125I]azido Photoaffinity Probe to the Human Platelet Thromboxane A2/Prostaglandin H2 Receptor. J. Labelled Compds and Radiopharmaceut., 25, 731-737.
41. Mais, D.E. and Halushka, P.V., 1988, Photoaffinity Labelling and Isoelectric Focusing of the Human Platelet Thromboxane A2/Prostaglandin H2 (TXA2/PGH2) Receptor. Proceedings of the Taipei Conference on Prostaglandins and Leukotriene Research. Adv. in Prostaglandin, Thromboxane, and Leukotriene Research, Vol. 19, 168-171.
42. Liel, N., Mais, D.E. and Halushka, P.V., 1989, Desensitization of Platelet Thromboxane A2/Prostaglandin H2 Receptors by the Mimetic U46619. J. Pharmacol. Exp. Ther., 247, 1133-1138.
43. Mais, D.E., Liel, N. and Halushka, P.V., 1990, Photoaffinity Receptor Antagonist for Human Platelet TXA2/PGH2 Receptors. Biochem. Pharm., 40, 1457-1461.
44. Mais, D.E., Yoakim, C., Guindon, J., Gillard, J. and Halushka, P.V., 1989, Photoaffinity Labelling of the Human Platelet TXA2/PGH2 Receptor. Biochem. Biophys. Acta, 1012, 184-190.
45. Halushka, P.V., Boehm, A. and Mais, D.E., 1988, Polymyxin B Increases TXA2/PGH2 Agonist and Antagonist Binding in Human Platelet Membranes. Eicosanoids, 1, 41-44.
46. Mayeux, P.R., Morton, H., Gillard, J., Lord, T., Morinelli, T., Buehm, A., Mais, D.E. and Halushka, P., 1988, The Affinities of Prostaglandin H2 and Thromboxane A2 for their Receptors are Similar in Washed Human Platelets. Biochem, Biophys. Res. Comm., 157, 733-739.
47. Halushka, P., Mais, D.E. and Morinelli, T., 1989, Thromboxane and Prostacyclin Receptors. In: Prostaglandins in Clinical Research: Cardiovascular System. Alan R. Liss Publishers, NY, NY. 21-28.
48. Mais, D.E. and Halushka, P., 1989, Photoaffinity Labelling of the Human Platelet Thromboxane A2/Prostaglandin H2 (TXA2/PGH2) Receptor. In: Prostaglandins in Clinical Research: Cardiovascular System. Alan R. Liss Publishers, NY, NY. 303-308.
49. Mais, D.E. and Halushka, P., 1989, [125I]PTA-OH: A Radioligand for the Characterization of Thromboxane A2/Prostaglandin H2 Receptors. Biotech Update, 4, 15.
50. Mayeux, P., Mais, D.E., Carr, C. and Halushka, P., 1989, Human Erythroleukemia Cells Express Functional Thromboxane A2/Prostaglandin H2 Receptors. J. Pharmacol. Exp. Ther., 250, 923-927.
51. Morinelli, T., Okwu, A., Mais, D.E., Halushka, P. and Fried, J., 1989, Diflourothromboxane A2 Isomers: Stable Analogs of Thromboxane A2 with Differential Effects on Platelets and Blood Vessels. Proc. Natl. Acad.Sci. USA, 86, 5600-5604.
52. Morinelli, T., Oatis, J., Okwu, A., Mais, D.E., Mayeux, P., Masuda, A., Knapp, D. and Halushka, P., 1989, Characterization of an [125I]-Labelled Thromboxane A2/Prostaglandin H2 Receptor Agonist. J. Pharmacol. Exp. Ther., 251, 557-562.
53. Dorn, G., Liel, N., Trask, J., Mais, D.E., Assey, M. and Halushka, P., 1990, Increased Platelet Thromboxane A2/Prostaglandin in Patients with Acute Myocardial Infarction. Circulation. 81, 212-218.
54. Halushka, P., Morinelli, T. and Mais, D.E., 1990, Radioligand Binding Assays for Thromboxane A2/Prostaglandin H2 Receptors. Methods in Enzymology. 187, 397-413.
55. Mayeux, P., Morinelli, T., Williams, T., Hazard, S., Mais, D.E., Oatis, J., Baron, D. and Halushka, P., 1991, Differential Effect of pH on Thromboxane A2/Prostaglandin H2 Receptor Agonist and Antagonist Binding in Human Platelets. J. Biol. Chem. 266, 13752-13758.
56. Mais, D.E., Saussy, D.L., Magee, D.E. and Bowling, N., 1990, Interaction of 5 HETE, 12-HETE, 15-HETE and 5,12-diHETE at the Human Platelet Thromboxane A2/Prostaglandin H2 Receptor. Eicosanoids. 3, 121-124.
57. Morinelli, T.A., Mais, D.E., Oatis, J.E., Crumbley, A.J. and Halushka, P.V., 1990, Characterization of Thromboxane A2/Prostaglandin H2 Receptors in Human Vascular Smooth Muscle Cells. Life Sciences. 46, 1766-1772.
58. Mayeux, P.R., Mais, D.E. and Halushka, P.V., 1991, Interactions of Dihydropyridine Calcium Channel Agonists with the Human Platelet Thromboxane A2/Prostaglandin H2 Receptor. Eur. J. Pharmacol. 206, 15-21.
59. Morinelli, T.A., Mais, D.E., Oatis, J.E., Mayeux, P.R., Okwu, A., Masuda, A., Knapp, D.R. and Halushka, P.V., 1990, IBOP, the Most Potent Radiolabelled Agonist for the TXA2/PGH2 Receptor. Current Trends in the Biology of Eicosanoids. 20, 102-109.
60. Masuda, A., Mais, D.E., Oatis, J.E. and Halushka, P.V., 1991, Platelet and Vascular Thromboxane A2/Prostaglandin H2 Receptors: Different Subclasses in the Rat. Biochem. Pharmacol. 42, 537-544.
61. Saussy, D.L., Mais, D.E., Dube’, G.P., Magee, D.E., Brune, K.A., Kurtz, W.L. and Williams, C.M., 1991, Characterization of a Thromboxane A2/Prostaglandin H2 Receptor in Guinea Pig Lung Membranes using a Radioiodinated Thromboxane Mimetic. Molecular Pharmacol. 39, 72-78.
62. Morinelli, T.A., Naka, M., Masuda, A., Oatis, J., Mais, D.E., Saussy, D.L. and Halushka, P.V., 1990, Characterization of Thromboxane A2/Prostaglandin H2 Receptors of Various Tissues using a New Radioiodinated Thromboxane A2/Prostaglandin H2 Mimetic, IBOP. Adv. in Prostaglandin, Thromboxane, and Leukotriene Res., 21A, 331-337.
63. Mais, D.E., Saussy, D.L., Jr., Magee, D.E., and Williams, C., 1990, Binding of a Radioiodinated Agonist to Thromboxane A2/Prostaglandin (TXA2/PGH2) Receptors in Guinea Pig Lung Membranes. Adv. in Prostaglandin, Thromboxane, and Leukotriene Res., 21A, 347-350.
64. Mais, D.E., Halushka, P.V., Naka, M., Morinelli, T., and Oatis, J., 1991, Radioiododestannylation. Convenient Synthesis of a High Affinity Thromboxane A2/Prostaglandin H2 Receptor Antagonist. J. Labelled Compds. and Radiopharmaceuticals. 29, 75-79.
65. Gehlert, D.R., Mais, D.E., Gackenheimer, S.L., Krushinski, J.H. and Robertson, D.W., 1990, Localization of ATP Sensitive Potassium Channels in the Rat Brain using a Novel Radioligand, 125I-Iodoglybenclamide. Eur. J. Pharmacol. 186, 373-375.
66. Robertson, D.W., Schober, D.A., Krushinski, J.H., Mais, D.E., Thompson, D.C., and Gehlert, D.R., 1990, Expedient Synthesis and Biochemical Properties of an 125I-Labelled Derivative of Glyburide, a Radioligand for ATP Inhibited Potassium Channels. J. Med. Chem. 33, 3124-3126.
67. Gehlert, D.R., Gackenheimer, S.L., Mais, D.E., and Robertson, D.W., 1991, Quantitative Autoradiography of the Binding Sites for 125I-Iodoglyburide, a High Affinity Ligand for ATP-Sensitive Potassium Channels in the Rat Brain. J. Pharmacol. Exp. Ther. 257, 901-907.
68. Mais, D.E., Mohamadi, F., Dube’, G.P., Kurtz, W.L., Brune, K.A., Utterback, B.G. and Jakubowski, J.A., 1991, Thromboxane A2 Receptor Antagonists. Synthesis and Activities of Benzenesulforamide Derivatives. Eur. J. Med. Chem. 26, 821-827.
69. Mais, D.E., Bowling, N.L., True, T.A., Halushka, P.V., Morinelli, T.A., Naka, M., Oatis, J.E. and Hamanaka, N., 1991, Novel Synthesis and Biochemical Properties of an [125I]labelled Photoaffinity Probe to the Thromboxane A2/Prostaglandin H2 Receptor. J. Med. Chem, 34, 1511-1514.
70. Saussy, D.L., Clark, P.D., Gunn, D.L.,and Mais, D.E., 1992, Binding of a Novel Radioiodinated Thromboxane A2/Prostaglandin H2 Antagonist to Guinea Pig Lung Membranes. Eicosanoids. 5, 1-4.
71. Naka, M., Mais, D.E., Morinelli, T.A., Hamanaka, N., Oatis, J.E. and Halushka, P.V., 1992, I-SAP; A High Affinity Radiolabeled Partial Agonist for Platelet Thromboxane A2/Prostaglandin H2 Receptors. J. Pharmacol. Exp. Ther. 262, 632-637.
72. Ladouceur, G., Mais, D.E., Jakubowski, J.A. and Robertson, D.W., 1991, Structural Homologies among Thromboxane Receptor Antagonists. Minimal Pharmacophoric Requirements for High Affinity Interaction with the Receptors. Bioorg. Med. Chem. Letters. 1, 173-178.
73. Gehlert, D.R., Gackenheimer, S.L., Mais, D.E., Littlefield,E. and Robertson, D.W. 1992, Autoradiographic Localization of Norepinephrine Uptake Sites in Rat Brain Using a Novel Radioligand, [125I]-Iodotomoxetine. Eur. J. Pharmacol. Submitted.
74. Dube, G.P., Mais, D.E.,Jakubowski, J.A., Brune, K., Utterback, B.G., True, T.A. Rinkema,L. and Kurtz, W.L., 1992, In Vitro Characterization of a novel TXA2/PGH2 receptor Ligand (S-145) in platelets and vascular and airway smooth muscle. J. Pharmacol. Exp. Ther., 262, 784-791.
75. Halushka,P.V., Morinelli,T.A., Masuda, A. and Mais, D.E. 1994, Thromboxane A2/Prostaglandin H2 Receptors: A growing family of receptor subtypes. Adv. in Prostaglandin, Thromboxane, and Leukotriene Res., 23, 234-239.
76. Halushka,P.V., Morinelli,T.A., Masuda, A. and Mais, D.E. 1994, Thromboxane A2/Prostaglandin H2 Receptors: A growing family of receptor subtypes. Adv. in Prostaglandin, Thromboxane, and Leukotriene Res., 23, 435-440.
77. Halushka,P.V., Morinelli,T.A., Masuda, A. and Mais, D.E. 1994, Thromboxane A2/Prostaglandin H2 Receptors: A growing family of receptor subtypes. Adv. in Prostaglandin, Thromboxane, and Leukotriene Res., 23, 543-547.
78. Halushka, P.V., Mais, D.E., Masuda,A., Morinelli, T.and Oatis, J.E. Jr., 1994, Thromboxane A2 Receptors: Characterization and Regulation. Adv. in Prostaglandin, Thromboxane, and Leukotriene Res., 24, 239-243.
79. Mais, D.E., True, T.A. and Martinelli, M.J., 1992, Purification and Characterization by Photoaffinity Labelling of the Human Platelet Thromboxane A2/Prostaglandin H2 Receptor. European J. Pharmacol. 227, 267-274.
80. Bowling, N., Dube', G.P., Kurtz, W.L., Brune, K. Watanabe, A.M. and Mais, D.E., 1994, Characterization of Thromboxane A2/Prostaglandin H2 Binding Sites in Guinea Pig Cardiac Membrane Preparations. J. Mol. Cell Cardiol. 26, 915-923.
81. Mais, D.E., Bowling, N.L. and Watanabe, A.M., 1992, Synthesis and Biochemical Properties of an [125I]-Labelled Ryanodine Derivative. Biochem. Biophy. Res. Comm., 183, 462-467.
82. Robertson, D.W., Littlefield, E.S., Mais, D.E., Gackenheimer, S.L. and Gehlert, D.R., 1992, Synthesis and Biochemical Characterization of an[125I]-Labeled Analogue of Tomoxetine, A Radioligand for the Norepinephrine Uptake Carrier. J. Med. Chem., Submitted.
83. Gehlert, D.R., Schober, D.A., Gackenheimer, S.L., Mais, D.E., Ladouceur, G. and Robertson, D.W., 1993, Synthesis and Evaluation of [125I]-(S)-Iodozacopride, A High Affinity Radioligand for 5HT3 Receptors. Neurochem. Int. 23, #4, 373-383.
84. True, T.A. and Mais, D.E., 1994, Localization of 125I-SAP-N3 Binding in the Human Platelet Thromboxane A2/Prostaglandin H2 Receptor by Proteolytic Cleavage Analysis. Eur. J. Pharmacol. 266, 51-55.
85. Okwu, A.K., Mais, D.E. and Halushka, P.V., 1994, Agonist Induced Phosphorylation of Human Platelet TXA2/PGH2 Receptors. Biochim. Biophys. Acta, 1221, 83-88.
86. Takeuchi, K., Happ, A.M., Mais, D.E., Layman, N., Utterback, B.G., Wyss, V.L. and Jakubowski, J.A., 1994, Development of Dual-Acting Agents for the Thromboxane Receptor. Antagonism and Thromboxane Synthase Inhibition. 1. Synthesis, Structure Activity Relationship, and Evaluation of substituted -phenyl--(3-pyridyl)alkenoic acids. Bioorg. and Med.Chem, 2, 743-755.
87. Jakubowski, J. A., Utterback, B.G., Mais, D.E., Hardinger, S.A., Braish, T., Neville, C. and Fuchs, P., 1994, Biochemical and Pharmacological Activity of Arene-Fused Prostacyclin Analogs on Human Platelets. Prostaglandins, 47, 189-200.


  1. Mais, D.E., Hayes, J.S., Heap, R.B. and Wang, M.-W., 1995, Specific interaction of progestins and anti-progestins with progesterone antibodies, plasma binding proteins and human recombinate receptor. J. Steroid Biochem. Molec. Biol., 54, 63-69.

89. Boehm, M.F., Zhang, L., Badea, B.A., White, S.K., Mais, D.E., Berger, E., McClurg, M., Suto, C., Goldman, M.E., Heyman, R.A.,1994, Synthesis and Structure Activity Relationships of Novel Retinoid X Receptor Selective Retinoids, J. Med. Chem.

37, 2930-2941.
90. Bowling, N., Mais, D.E., Gerzon, K. and Watanabe, A.M., 1994, Ryanodine and an iodinated analog: doxorubicin effects on binding and calcium accumulation in cardiac sarcoplasmic reticulum. Eur. J. Pharmacol. 268, 365-373.
91. Mais, D.E., Berger, E., Zhang, L., Boehm, M., 1994, Biochemical Properties of a novel RXR selective radiolabelled ligand. Med. Chem. Res. 4, 406-413.
92. Wen, D.X., Xu, Y.F., Mais, D.E., Goldman, M.E. and McDonnell, D.P., 1994, The A and B- isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells. Mol. Cell Biol. 14, 8356-8364.
93. Pithirana, C., Stein, R.B., Berger, T.S., Fenical, W., Ianiro, T., Mais, D.E., Torres, A. and Goldman, M.E., 1995, Identification of non-steroidal human progesterone receptor ligands from secondary metabolites of the marine alga Cymopolia Barbata. Mol. Pharmacol.

47, 630-635.


94. Nunes, J.J., Quimby, M.E., Mais, D.E. and Jakubowski, J.A., 1996, Synthesis and Platelet Inhibitory activity of a series of novel monobactams. Bioorg. and Med. Chem Letters, 5, 56-64.
95. Zhang, L., Badea, B.A., Enyeart, D.L., Berger, E.M., Mais, D.E. and Boehm, M.F., 1995, Synthesis of isotopically labelled LGD1069, a potent retinoid X receptor selective ligand.J. Labelled Comp. and Radiopharm., 36, 7, 701-712.
96. Margolin, N., True, T.A., Saussy, D.L. and Mais, D.E., 1994, Effect of Alkaline Phosphatase on Thromboxane Mimetic Induced Platelet Activation. Prostaglandins 48, 235-246.
97. Nadzan, A., Boehm, M., Zhang, L., Badea, B.S., White, S., Mais, D., Berger, E., Suto, C., Goldman, M., McClurg, M. and Heyman, R., 1995, Design of novel RXR selective retinoids. European J. Med. Chem., 30, 519s-533s.
98. Mais, D.E., Chen, L.-Z., Wagoner, M.A., Hayes, J.S. and Wang. M.-W., 1995, Synthesis and Characterization of Tritium-Labeled RU486. J. Labelled Comp. and Radiopharm. 36, #12, 1199-1203.
99. Boehm, M.F., Zhang, L., McClurg, M.R., Berger, E., Wagoner, M., Mais, D.E., Suto, C.M., Davies, P., Heyman, R.A. and Nadzan, A.M., 1995, Design and Synthesis of Potent Retinoid X Receptor Selective Ligands that induce Apoptosis in Leukemia Cells. J. Med. Chem. 38(16), 3146-3155.
100. Wang, M.W., Crombie, D.L., Mais, D.E., Hayes, J.S. and Heap, R.B., 1995, Anti-progesterone antibody administration and the impairment of postpartum maternal care in mice. J. Endocrinology., 145(2), 363-369.
101. Kitareewan, S., Burka, L., Tomer, K., Parker, C., Detering, L., Stevens, R., Mais, D.E., Heyman, R., McMorris, T. and Weinberger, C., 1996, Phytol Metabolites are Circulating Dietary Factors that Activate the Nuclear Receptor RXR. Molecular Biol. of the Cell., 7, 1153-1166.
102. Bennani, Y.L., Marron, K.S., Mais, D.E., Flatten, K.Nadzan, A.M. and Boehm, M.F.(1997), Synthesis and Characterization of a highly potent and Selective Isotopically Labeled RAR-Ligand ALRT1550. J. Org. Chem., 63, 543-550.
103. Mais, D.E., Hamann, L., Klausing, K., Paterniti, J., and Mukherjee, R.(1997) Synthesis and Evaluation of a Potent Radiolabelled Probe to the Human Peroxisome proliferator Activator Receptor. Medicinal Chem. Research, 7:5, 325-334.
104. Jones, T.K., Pathirana, C., Goldman, M.E., Hamann, L.G., Farmer, L.J., Ianiro, T., Johnson, M.G., Bender, S.L., Mais, D.E. and Stein, R.B., 1996, Discovery of Novel Intracellular Receptor Modulating Drugs. J. Steroid Biochem. Molec. Biol., 56, 61-6.
105. Zhang, L., Nadzan, A.M., Hayman, R.A., Love, D., Mais, D.E., Croston, G., Lamph, W.I., Boehm, M.F., 1996, Discovery of Novel Retinoic Acid Receptor Agonists having Potent Antiproliferative Activity in Cervical Cancer cell. J. Med. Chem., 39, 2659-2663.

106. Hamann, L.G., Farmer, L.J., Johnson, M.G., Goldman, M.E., Mais, D.E., Davtian, A., Bender, S.L., Jones, T.K., 1995, Synthesis and biological activity of novel nonsteroidal progesterone receptor antagonists. Annals of the New York Academy of Sciences 761, 383-387.


107. Hamann, L.G., Farmer, L.J., Johnson, M.G., Bender, S.L., Mais, D.E., Wang, M.W., Crombie, D., Goldman, M.E.and Jones, T.K., 1996, Synthesis and biological activity of novel nonsteroidal progesterone receptor antagonists based on cyclocymopol monomethyl ether. J. Med. Chem., 39(9), 1778-1789.
108. Wagner, B.L., Pollio, G., Giangrande, P., Webster, J.C., Breslin, M., Mais, D.E., Cook, C.E., Vedeckis, W.V., Cidlowski, J.A. and McDonnell, D.P., 1999, The Novel Progesterone Receptor antagonists RTI 3021-012 and RTI 3021-022 exhibit complex Glucocorticoid receptor antagonist activities: Implications for the development of dissociated antiprogestins. Endocrinology, 140, 1449-1458.
109. Zuo, A., Marschke, K., Arnold, K., Berger, E., Fitzgerald, P., Mais, D.E., Allegretto, E.A., 1999, Estrogen receptor beta protein endogenously expressed in bone cancer cells is transcriptionally active. J Molecular Endo., 13, 418-430.
110. Pawate, S.,Schey, K.L., Meier, G.P., Ullian, M.E., Mais, D.E. and Halushka, P.V., 1998, Expression, Characterization and Purification of C-terminally hexahistidine tagged thromboxane A2 receptors. J Biol. Chem. 273: 22753-22760.
111. Edwards, J.P., West, S.J., Marschke, K.B., Mais, D.E., Gottardis, M. and Jones, T.K., 1998, 5-Aryl 1,2-Dihydro-5H-chromeno[3,4-f]quinolines as Potent, Orally active, Non-steroidal Progesterone Receptor Agonists: The Effect of D-Ring Substituents. J. Med. Chem. 41, 303-310.


  1. Zhi, L., Tegley, C.M., Kallel, E.A., Marschke, K.B., Mais, D.E., Gottardis, M. and Jones, T.K., 1998, 5-Aryl 1,2-Dihydrochromeno[3,4-f]quinolines, A Novel Class of Nonsteroidal Human Progesterone Receptor Antagonists. J. Med. Chem. 41, 291-302.




  1. Boehm, M.F., Fitzgerald, P., Zou, A., Elgort, M., Bischoff, E.D., Mere, L., Mais, D.E., Bissonnette, R.P., Heyman, R.A., Nadzan, A.M., Reichman M. and Allegretto, E.A. 1999, Novel Nonsecosteroidal Vitamin D3 Mimics Exert VDR Modulating Activities with less Calcium Mobilization than 1,25-Dihydroxyvitamin D3. Chemistry and Biology. 6:265-275

114. Takeuchi, K., Mais, D.E., True, T.A., Wyss, V.L. and Jakubowski, J.A., 1998, Development of Dual-Acting Agents for Thromboxane Receptor Antagonism and Thromboxane Synthase Inhibition. 2. Design, Synthesis and Evaluation of a Novel Series of Phenyl Oxazole Derivatives. Bioorg. Med. Chem. Lett. 8, 1943-1948


115. Takeuchi, K., Kohn, T.J., True, T.A., Mais, D.E., Wikel, J.H., Utterback, B.G., Wyss, V.L. and Jakubowski, J.A., 1998, Development of Dual-Acting Agents for Thromboxane Receptor Antagonism and Thromboxane Synthase Inhibition. 3. Synthesis and Biological Acyivities of Oxazolecarboxamide-substituted o-phenyl--(3-pyridyl)alkenoic Acid Derivatives and Related Compounds. J. Med. Chem. 41, 5362-5374


  1. Edwards, J.P., Marschke, K.B., West, S.J., Mais, D.E., Gottardis, M.M. and Jones, T.K., 1998, 5-Benzylidene-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines: Potent, nonsteroidal, selective progesterone receptor modulators. J. Med. Chem. Submitted

117. Hamann, L.G., Winn, D.T., Pooley, C.L.F., Tegley, C.M., West, S.J., Farmer, L.J., Edwards, J.P., Marschke, K.B., Mais, D.E., Goldman, M.E. and Jones, T.K., 1998, Non-steroidal progesterone receptor antagonists based on a conformationally-restricted sub-series of 6-aryl-1,2-dihydro-2,2,4-trimethylquinolines. Bioorg. and Med. Chem. Letters, 8, 2731-2736.




  1. Zhi, L., Tegley, C.M., Edwards, J.P.,West, S.J., Marschke, K.B., Gottardis, M., Mais, D.E. and Jones, T.K., 1998, 5-Alkyl 1,2-Dihydrochromeno[3,4-f]quinolines, A Novel Class of Nonsteroidal Human Progesterone Receptor Agonists. Bioorg. and Med. Chem. Letters, 8, 3365-3370.




  1. Zhi, L., Tegley, C.M., Marschke, K.B., Mais, D.E. and Jones, T.K., 1999, 5-Aryl-1,2,3,4-tetrahydrochromeno[3,4-f]quinolin-3-ones as a Novel Class of Nonsteroidal Progesterone Receptor Agonists: Effect of A-Ring Modification. J. Med. Chem., 42(8), 1466-1472.




  1. Mukherjee, R., Hoener, P.A., Jow, L., Bilakovics, J., Klausing, K., Mais, D.E., Faulkner, A., Croston, G.E. and Paterniti, J.R., 2000, A Selective PPAR modulator blocks adipocyte differentiation but stimulates glucose uptake in 3T3-L1 adipocytes. Mol. Endo., 14(9), 1425-1433.




  1. Zhi, L., Tegley, C.M., Pio, B., West, S.J., Marschke, K.B., Mais, D.E., and Jones, T.K., 2000, Nonsteroidal progesterone receptor antagonists based on 6-thiophenehydroquinolines. Biorg. Med. Chem. Letters, 10(5): 415-418.




  1. Michellys, P.Y., Ardecky, R.J., Chen, J.H., Crombie, D.L., Etgen, G., Faul, M., Faulkner, A.L., Grese, T.A., Heyman, R.A., Karanewsky, D.S., Klausing, K., Leibowitz, M.D., Liu, S., Mais, D.E., Mapes, C.M., Marschke, K., Reifel-Miller, A., Ogilvie, K.M., Rungta, D., Thompson, A.W., Tyhonas, J.S. and Boehm, M.F., 2003, Novel (2E,4E,6Z)-7-(2-Alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic Acid

Retinoid X Receptor Modulators Are Active in Models of Type 2 Diabetes, J. Med.Chem., 46, 2683-2696.


  1. Mapes, C.M., Ardecky, R.J., Boehm, M.F.Chen, J.H., D’Arrigo, J., Grese, T.A., Karanewsky, D.S., Leibowitz, M.D., Liu, S., Mais, D.E., Reifel-Miller, A., Ogilvie, K.M., Rungta, D., Thompson, A.W., Tyhonas, J.S. and Michellys, P.Y., 2003, Design and Synthesis of New Dienoic Acid RXR Modulators, J. Med. Chem., Submitted




  1. Zhi L, Tegley CM, Pio B, Edwards JP, Jones TK, Marschke KB, Mais DE, Risek B and Schrader WT. Synthesis and biological activity of 5-methylidene 1,2-dihydrochromeno[3,4-f]quinoline derivatives as progesterone receptor modulators. Bioorganic & Medicinal Chemistry Letters 2003; 13 (12):2071-2074

125. Zhi L, Ringgenberg JD, Edwards JP, Tegley CM, West SJ, Pio B, Motamedi M, Jones TK, Marschke KB, Mais DE and Schrader WT. Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore. Bioorganic & Medicinal Chemistry Letters 2003; 13 (12):2075-2078


BOOK CHAPTERS AND INVITED REVIEWS
1. Halushka, P., Mais, D.E. and Saussy, D., 1994, Platelet and Vascular Smooth Muscle Thromboxane A2/Prostaglandin H2 Receptors. Atherosclerosis Reviews. 23, 348-368.
2. Mais, D.E., Halushka, P. and Saussy, D., 1988, Platelet and Vascular Smooth Muscle Thromboxane A2/Prostaglandin H2 Receptors. Eicosaniods in the Cardiovascular and Renal Systems. Eds. Halushka, P. and Mais, D.E. 210-231.
3. Halushka, P., Mais, D.E., Dorn, G.W., II, and Liel, N., 1988, A Role for Thromboxane A2 in Cardiovascular and Renal Diseases? Emory J. of Medicine, 2, 19-32.
4. Halushka, P. and Mais, D.E., 1989, Basic and Clinical Pharmacology at Thromboxane A2. Drugs of Today, 25, 383-393.
5. Halushka, P., Mais, D.E., Mayeux, P. and Morinelli, T., 1989, Thromboxane, Prostaglandin and Leukotriene Receptors. Ann. Rev. Pharmacol. and Toxicol., 29, 213-239.
6. Boehm, M.F., Suto, C.M., Mais, D.E. and Heyman, R.A., 1994, Gene Expression as a target for drug discovery: Identification of endogenous ligands and novel drug candidates for Intracellular Receptors. Receptor Research Methods, Ch. 15, 319-338.


  1. Hamann, L.G., Farmer, L.J., Johnson, M.G., Goldman, M.E., Mais, D.E., Davtian, A., Bender, S.L., Jones, T.K., 1995, Synthesis and biological activity of novel nonsteroidal progesterone receptor antagonists. In Steroid Receptors and Antihormones, (edited by D. Henderson, D. Philibert, A.K. Roy and G. Teutsch). The New York Acad. Sciences, New York, Vol. 761, pg 383-387.

8. Mais, D.E., 2001, Retinoid Receptors as Targets for Oncology. In Cancer Chemotherapy and Prevention, Edited by Rui Han, Yan Sun and Dao Pei Lu, Scince Press, Beijing, PRC 100717




BOOKS


  1. EICOSANOIDS IN THE CARDIOVASCULAR AND RENAL SYSTEMS. 1988, EDS. P.V. Halushka and D.E. Mais, M.J.P. Press Ltd., Lancaster, England.


ABSTRACTS:
1. Mais, D.E. and Bosin, T., 1982, Effect of Hyperoxia on Serotonin Disposition and Metabolism. ASPET Meeting, Louisville, KY.
2. Mais, D.E. and Bosin, T., 1983, Altered Pulmonary Serotonin (5-HT) Disposition and Metabolism with Alpha-Naphthylthiourea. FASEB Meeting, Chicago, IL.
3. Bosin, T. and Mais, D.E., 1983, Role of Serotonin in Alpha-Naphthylthiourea-Induced Pulmonary Edema. INDIANA THORACIC SOCIETY, Indianapolis, IN.
4. Bosin, T. and Mais, D.E., 1984, The Role of Serotonin in Alpha-Naphthylthiourea Induced Pulmonary Edema. FASEB Meeting, St. Louis, MO.
5. Bosin, T., Lahr, P. and Mais, D.E., 1984, Hyperoxia and Paraquat Alter Platelet Serotonin Uptake Kinetics. ASPET Meeting, Indianapolis, IN.
6. Mais, D.E., Halushka, P., Knapp, D., Kochel, P. and Arai, Y., 1984, Evidence for a Difference in Platelet and Vascular Thromboxane A2 Receptors. FASEB Meeting, St. Louis, MO.
7. Halushka, P., Chaikhouni, D., Mais, D.E., Knapp, D., Saussy, D. and Arai, Y., 1984, Thromboxane A2 (TXA2)/Prostaglandin H2 (PGH2) Receptors are Different in Platelets and Blood Vessels. IUPHAR 9th International Congress of Pharmacology, London, England.
8. Halushka, P., Mais, D.E., Knapp, D., Saussy, D., Kochel, P. and Arai, Y., 1984, Thromboxane A2 (TXA2)/Prostaglandin H2 (PGH2) Receptors Differ in Platelets and Blood Vessels. Washington Spring Symposium, Washington, D.C.
9. Halushka, P., Saussy, D., Mais, D.E., and Knapp, D., 1984, A Novel Approach for the Study of TXA2/PGH2 Receptors using 125I Labelled Ligand. Winter Prostaglandin Conference, Boulder, CO.
10. Saussy, D., Mais, D.E., Knapp, D., Halushka, P., and Hamanaka, N., 1984, Binding of Thromboxane (TXA2) Receptor Antagonist to Human Platelet Membranes. Kinins, Savannah, GA.
11. Halushka, P., Saussy, D., Mais, D.E., Chaikhouni, D., Knapp, D., Dorn, G., Kochel, P. and Hamanaka, N., 1984, Human TXA2 Receptors are Different in Platelets and Blood Vessels. Kyoto Prostaglandin Conference, Kyoto, JAPAN.
12. Saussy, D., Mais, D.E., Knapp, D., and Halushka, P., 1984, Identification of a Putative Thromboxane A2/Prostaglandin H2 Receptors in Human Platelets using a 125I-Labelled Receptor Antagonist. American Heart Association, Miami, FL.
13. Mais, D.E., Kochel, P., Saussy, D., Halushka, P., 1985, Binding of a 125I-Labelled Thromboxane A2 (TXA2/Prostaglandin H2 (PGH2) Receptor Antagonist to Washed Canine Platelets. FASEB Meeting, Anaheim, CA.
14. Eller, T., Vrbanac, J.,Mais, D.E., Halushka, P., Baker, R. and Knapp, D., 1985, Isolation of Thromboxane-B2 from Urine using an Immobilized Antibody. Winter Prostaglandin Conference, Keystone, CO.
15. Burch, R., Mais, D.E., Knapp, D., and Halushka, P., 1985, Solubilization of a Human Platelet Thromboxane A2/Prostaglandin H2-Antagonist Binding Site. Accepted for American Society of Clinical Research Meeting, May 1985, Washington, D.C.
16. Halushka, P., Dorn, G., Burch, R., Mais, D.E., and Kochel, P., 1985, Decreased Affinity of Platelet Thromboxane A2/Prostaglandin H2 Receptors for TXA2/PGH2 Mimetics Induced by Supernatant of Platelet Homogenates. International Conference on Leukotrienes and Prostanoids in Health and Disease, Israel.
17. Mais, D.E., and Halushka, P., 1985, Binding of a Thromboxane A2/Prostaglandin H2 Receptor Antagonist to Washed Human Platelets. Louis N. Katz Finalist Presentation, American Heart Association, Washington, D.C.
18. Dorn, G., Burch, R., Mais, D.E., and Halushka, P., 1985, Alteration of Platelet Thromboxane A2/Prostaglandin H2 Receptors by Supernatant of Platelet Homogenates. American Heart Association, Washington, D.C.
19. Saussy, D., Mais, D.E., and Halushka, P., 1985, Characterization of a Putative Thromboxane A2/Prostaglandin H2 Receptor in Human Platelet Membranes. J. Clin. Pharmacol. 25, 636.
20. Halushka, P., Mais, D.E., Garvin, M., Kochel, P. and Sightler, H., 1986, Structure-Activity Relationships for 13-azapinane-TXA2 Analogs in Platelet and Vascular TXA2/PGH2 Receptors: Evidence for Different Receptors. Sixth International Conference on Prostaglandins and Related Compounds, Florence, Italy.
21. Mais, D.E., Burch, R., and Halushka, P., 1986, Photoaffinity labelling of the Human Platelet TXA2/PGH2 Receptor. Sixth International Conference on Prostaglandins and Related Compounds, Florence, Italy.
22. Saussy, D., Mais, D.E., and Halushka, P., 1985, Characterization of a Putative Thromboxane A2/Prostaglandin H2 Receptor in Human Platelet Membranes. Society for Experimental Biology and Medicine, Southeastern Section. Charleston, SC.
23. Mais, D.E., Halushka, P., and DeHoll, D., 1987, Photoaffinity labelling of the Human Platelet TXA2/PGH2 Receptor: Evidence for Spare Receptors. FASEB Meeting, Washington, D.C.
24. Dorn, G.W., Mais, D.E., Kochel, P.J.and Halushka, P.V., 1986, Modulation of Agonist Affinity for Human Platelet Thromboxane A2 and -adrenergic Receptors by Platelet Supernatant. Circulation 74: II-324.
25. Liel, N., Mais, D.E., and Halushka, P.V., 1987, Desensitization of Platelet Thromboxane A2 Receptors by the Agonist U46619. American Heart Association, 60th Scientific Sessions, November 16-19.
26. Dorn, G.W., Liel, N., Trask, J., Assey, M., Mais, D.E., and Halushka, P.V., 1987, Increased Platelet Thromboxane Receptors in Acute Coronary Ischemic Syndromes.
27. Halushka, P.V., and Mais, D.E., 1988, Characterization of Human Platelet Thromboxane A2/Prostaglandin H2 (TXA2/PGH2) Receptors via Photoaffinity Labelling. Taipei Conference on Prostaglandin and Leukotriene Research, April 22-24.
28. Mais, D.E., and Halushka, P.V., 1988, Characterization of Human Platelet Thromboxane A2/Prostaglandin H2 (TXA2/PGH2) Receptors using Photoaffinity Labelling. American Heart Association, November.
29. Morinelli, T.A., Okwu, A.K., Mais, D.E., Oatis, J. and Halushka, P.V., 1988, I-BOP a New, Potent Thromboxane A2/Prostaglandin H2 Receptor Agonist. American Heart Association, November.
30. Mayeux, P.R., Morinelli, T.A., Mais, D.E., Morton, H.E., Gillard, J., Lord, A. and Halushka, P.V., 1988, The Affinity of Thromboxane A2 (TXA2) is not greater than Prostaglandin H2 (PGH2) in Washed Human Platelets (WHP). FASEB Meeting, November.
31. Morinelli, T.A., Mayeux, P.R., Mais, D.E., Oatis, J., Williams, T., Hazard, S., Baron, D. and Halushka, P.V., 1988, Increased Agonist Affinity and Density for Human Platelet (HP) TXA2/PGH2 Receptors at Low pH. FASEB Meeting, November.
32. Mais, D.E., Mayeux, P.R. and Halushka, P.V., 1988, Dihydropyridines (DHP) Interact with the Human Platelet Thromboxane A2/Prostaglandin H2 (TXA2/PGH2) Receptor. FASEB Meeting, November.
33. Naka, M., Mais, D.E., Morinelli, T., Oatis, J., Hamanaka, N. and Halushka, P.V., 1989, ISAP, a New High Affinity Thromboxane A2 Prostaglandin H2 Receptor Antagonist. American Heart Association, 60th Scientific Sessions, November 13-16.
34. Morinelli, T.A., Mais, D.E., and Halushka, P.V., 1989, Characterization of the Thromboxane A2 Receptor (TXA2R) on Cultured Human Vascular Smooth Muscle Cells (VSMC). American Heart Association, 60th Scientific Sessions, November 13-16.
35. Dube’, G., Kurtz, W., Mais, D.E., Brune, K., Fleisch, J., and Jakubowski, J., 1989, In Vitro Profile of a Novel Thromboxane A2 Antagonist in Platelets and Arteries. American Heart Association, 60th Scientific Sessions, November 13-16.
36. Okwu, A.K., Mais, D.E., Oatis, J.E. and Halushka, P.V., 1990, Mechanism of Homologous Desentization of Human Platelet Thromboxane A2 Receptor (TXA2) Receptors. FASEB Meeting, April.
37. Saussy, D.L., Mais, D.E., Magee, D.E., Dube’, G.P., Brune, K.A., Kurtz, W.L. and Williams, C.M., 1990, Characterization of TXA2/PGH2 Receptors in Guinea Pig Lung Membranes (GPLM) using a New Radioordinated Agonist. FASEB Meeting, April.
38. Mais, D.E., Saussy, D.L., Magee, D.E., and Bowling, N., 1990, Interaction of Hydroxyercosatetraenoic Acids at the Human Platelet Thromboxane A2/Prostaglandin H2 (TXA2/PGH2) Receptor. FASEB Meeting, April.
39. Masuda, A., Mais, D.E., and Halushka, P.V., 1990, 13-Azapinane Thromboxane A2 Analogs: Discriminators of Platelet and Vascular Thromboxane A2 Receptors. American Society of Clinical Investigation.
40. Mais, D.E., Saussy, D.L., Magee, D.E., Dube’, G.P., Brune, K.A., Kurtz, W.L. and Williams, C.M., 1990, Binding of a Radioiodinated Agonist to Thromboxane A2/Prostaglandin H2 (TXA2/PGH2) Receptors in Guinea Pig Lung Membranes. 7th International Conference on Prostaglandins and Related Compounds. Florence, Italy. May 28-June 1.
41. Naka, M., Mais, D.E., Morinelli, T.A., Oatis, J.E., Hamanaka, N. and Halushka, P.V., 1990, Characterization of a New High Affinity Thromboxane A2/Prostaglandin H2 (TXA2/PGH2) Receptor Antagonist: I-SAP. 7th International Conference on Prostaglandins and Related Compounds. Florence, Italy. May 28-June 1.
42. Halushka, P.V., Hamanaka, N., Mais, D.E., Masuda, A., Morinelli, T., Naka, M., Oatis, J.E. and Okwu, A., 1990, Characterization of Human Platelet Thromboxane A2 Receptors.7th International Conference on Prostaglandins and Related Compounds. Florence, Italy. May 28-June 1.
43. Dube’, G., Mais, D.E., Jakubowski, J.A., Kurtz, W., Utterback, B., Spees, M. and Mohamadi, F., 1990 Structure Activity Relationships for a Series of Benzenesulfonamides at Platelet and Aortic TXA2/PGH2 Receptors. ASPET Meeting, August.
44. Robertson, D.W., Krushinski, J., Mais, D.E., Thompson, D., Zimmerman, K. and Steinberg, M., 1990, Synthesis and Biological Characterization of [125I] Labelled LY285110, A Potential Biochemical Probe of ATP-Inhibited Potassium (K) Channels. Amer. Chem. Soc. Meeting, August.
45. Ladouceur, G., Mais, D.E., Klimkowski, J., Jakubowski, J. and Robertson, D., 1990, Structural Homologies Among Thromboxane Receptor Antagonists. Minimal Pharmacophoric Requirements for High Affinity Interaction with Thromboxane Receptors. Amer. Chem. Soc. Meeting, August.
46. Gehlert, D.R., Gackenheimer, S.L., Schober, D.S., Krushinski, J.H., Mais, D.E., Thompson, D.C. and Robertson, D.W., 1990, Localization of ATP-sensitive Potassium Channels in Rat Brain Using a Novel Radioligand, [125I]-Iodoglyburide. Annual Meeting of Amer. College of Neurophsychopharmacology, December.


  1. Robertson, D.W., Gackenheimer, S.L., Krushinski, J., Littlefield,E., Mais, D.E., Schober, D., Thompson, D. and Gehlert, D.E.,1991, [125I]-Iodoglyburide: Structure-Activity Relationships and its use for Rapid Autoradiographic Studies ofATP-Inhibited Potassium(K) Channels. Amer. Chem. Soc.

48. Utterback, B.G., Jakubowski, J.A., Ladouceur, G., Mais, D.E., Klimkowski, V.J. and Robertson,D.W. 1991, Minimal Pharmacophoric Requirements for High Affinity Interaction of Thromboxane A2/Prostaglandin H2 (TXA2/PGH2) Receptor Antagonists with TXA2/PGH2 Receptors. Washington Prostaglandin Meeting, May.


49. Mais, D.E., True, T.A., Martinelli, M.J., Halushka, P.V., Morinelli, T.A., Naka, M. and Oatis, J.E., 1991, Purification of the Human Platelet Thromboxane A2/Prostaglandin H2 Receptor and Characterization by Photoaffinity Labelling. Washington Prostaglandin Meeting, May.
50. True, T.A., Mais, D.E., Bowling, N.L., Halushka, P.V., Morinelli, T.A., Naka, M., Oatis, J.E. and Hamanaka, N., 1991, Synthesis and Biochemical Properties of a Novel [125I]-Labelled Photoaffinity Probe for the Thromboxane A2/Prostaglandin H2 Receptor. Washington Prostaglandin Meeting, May.
51. Saussy, D.L., Gunn, D.L., Clark, P.D. and Mais, D.E., 1991, Binding of a Novel Radioiodinated Thromboxane A2/Prostaglandin H2 Antagonist to Guinea Pig Lung Membranes. Washington Prostaglandin Meeting, May.
52. Halushka, P.V., Mais, D.E. and Masuda, A.,1991, Platelet and Vascular Thromboxane A2/Prostaglandin H2 Receptors: Characterization and Regulation. Washington Prostaglandin Meeting, May.
53. Gackenheimer, S.L., Littlefield, E.S., Mais, D.E., Robertson, D.W. and Gehlert, D.R., 1991, Autoradiographic Localization of Norepinephrine uptake sites in Rat Brain using [125I]-Iodotomoxetine. Society for Neuroscience. New Orleans, November.
54. Gehlert, D.R., Mais, D.E., Wong, D.T. and Robertson, D.W., 1992, [125I]-Iodotomoxetine, a Novel Radioligand for Norepinephrine uptake sites in Brain.Winter Conference on Brain Research. January.
55. Bowling, N.L., Dube, G.P., Kurtz, W.L., Brune, K. and Mais, D.E., 1991, Characterization of Thromboxane A2 Binding Sites in Guinea Pig Cardiac Membrane Preparations. American Heart Association, Anaheim, CA, November.
56. Gehlert, D.R., Wong, D.T., Mais, D.E. and Robertson, D.W., 1992, Novel Tomoxetine analogs with High Affinity and Selectivity for the Norepinephrine Transporter.Collegium Internationale Neuro-Psychpharmacologicum. Nice, France.
57. Saussy, D.L., Froelich, L.L., Cooley, B.A. and Mais, D.E., 1992, Modulation of Agonist Affinity for Thromboxane A2 (TXA2) Receptors on Guinea Pig Lung Membranes(GPLM) by Divalent Cations. FASEB Meeting, April, Anaheim, CA.
58. Gehlert, D.R., Schober, D.A., Gackenheimer, S.L., Ladouceur, G., Mais D.E. and Robertson, D.W., 1992, Synthesis and Characterization of [125I]-(S)-Iodozacopride, a Radioligand for the 5HT3 Receptors in Brain. ASPET Meeting, Anaheim, CA.
59. Margolin, N., Saussy, D.L., True, T.A. and Mais, D.E., 1992, Effect of Alkaline Phosphatase on Thromboxane Mimetic Induced Platelet Activation. 8th International Conference on Prostaglandins and Related Compounds. Montreal, Canada.
60. True, T.A. and Mais, D.E.,1992, Localization of [125I]-SAP-N3 Binding in the Human Platelet TXA2/PGH2 Receptor. 8th International Conference on Prostaglandins and Related Compounds. Montreal, Canada.
61. Gehlert, D.R., Schober, D.A., Gackenheimer, S.L., Ladouceur, G., Mais,. D.E. and Robertson, D.W. 1992, Synthesis and Characterization of [125I]-(S)-Iodozacopride, a Radioligand for 5HT3 Receptors in Brain. 2nd International Symposium on Serotonin from Cell Biology to Pharmacology and Therapeutics. Houston, TX.
62. Bowling, N., Mais, D.E., Gerzon, K. and Watanabe, A.M. 1992, Ryanodine and an Iodinated Analogue: Binding Properties and Effects on Calcium Uptake in the presence of Doxorubicin in Canine Cardiac Sarcoplasmic Reticulum. American Heart Association, New Orleans, LA, November.
63. Mais, D.E., Heap, R.B. and Wang, M.-W., 1994, Specific interaction of progestins and anti-progestins with progesterone receptor, antibodies and plasma binding proteins. Endocrine Society, Anahiem, CA.


  1. Xu, Y.F., Wen, D.X., Mais, D.E. and McDonnell, D.P., 1994, Transcription activation and repression functions of the human progesterone receptor can be separated by specific carboxyl terminal mutations. Endocrine Society, Anahiem, CA.

65. Shahbaz, M.M., Mais, D.E., Goldman, M.E., McDonnell, D.P. and Gleeson, M.A.G., 1994, Analysis of ligand specificity in androgen receptor isoforms with mutations in the ligand binding domain. Endocrine Society, Anahiem, CA.


66. Bennani, Y.L., Boehm, M.F., Shirley, M.A., Mais, D.E., Enyeart, D.and Brau, A.P., 1994, Syntheses and Utility of Isotopically Ring-Labeled 9-cis-Retinoic Acids. Gordon Conference in Medicinal Chemistry, New London, NH.
67. Pathirana, C., Stein, R.B., Berger, T.S., Fenical, W., Ianiro, T., Mais, D.E., Torres, A. and Goldman, M.E., 1994, Identification of non-steroidal human progesterone receptor ligands from secondary metabolites of the marine alga Cymopolia Barbata. International Congress on Natural Products. Halifax, Canada.
68. Hamann, L.G., Farmer, L.J., Johnson, M.G., Goldman, M.E., Mais, D.E., Davtian, A., Bender, S.L. and Jones, T.K., 1994, Synthesis and biological activity of novel non-steroidal progesterone receptor antagonists. Dallas, TX.
69. Thacher, S., Klein, E., Arefieg, T., Mais, D., Suto, C. and Chandraratna, R. !995, The Comparative Pharmacology of the acetylenic retinoid 190168 in skin and receptor-based assays. American Academy of Dermatology.
70. Boehm, M., Zhang, L., Badea, B.S., White, S., Mais, D., Berger, E., Suto, C., Goldman, M. and Heyman, R., 1994, Synthesis and structure activity relationships of novel retinoid X receptor selective retinoids. Med. Chem. Gordon Conference, Aug. 7-12.
71. Nadzan, A., Boehm, M., Zhang, L., Badea, B.S., White, S., Mais, D., Berger, E., Suto, C., Goldman, M., McClurg, M. and Heyman, R., 1994, Design of novel RXR selective retinoids. XIII International Symposium on Medicinal Chemistry, Paris, France Sept. 19-23.
72. Boehm, M., Zhang, L., Badea, B.S., McClurg, M., Mais, D., Berger, E., Suto, C. and Heyman, R., 1994, Discovery and biological activity of a novel class of retinoid X receptor selective retinoids. FASEB, Copper Mountain, CO. June 12-17.

73. Zhang, L., Badea, B.A., Enyeart, D., Berger, E.M., Mais, D.E. and Boehm, M.F., 1995, Synthesis and Biological Utility of Isotopically Labeled 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethenyl]benzoic acid (LGD1069). 209th American Chemical Society National Meeting, Anaheim, CA.


74. Canon Koch, S.S., Dardashti, L.J., Zhang, L., Badea, B.A., Boehm, M.F., Suto, C.M., Goldman, M.E., Enyeart, D.L., Berger, E., Mais, D.E. and Nadzan, A.M., 1995, Synthesis of Potent Retinoid X Selective Ligands. "Retinoids '95" Conference, Nice, France October 8-11.
75. Boehm, M.F., Zhang, L., Zhi, L., McClurg, M.R., Berger, E., Wagoner, M., Mais, D.E., Suto, C.M., Davies, P., Heyman, R.A. and Nadzan, A.M., 1995, Design and Synthesis of Potent Retinoid X Receptor Selective Ligands that induce Apoptosis in Leukemia Cells.Med. Chem. Gordon Conference.
76. Nadzan, A., Boehm, M., Zhang, L., Badea, B., Canon Kock, S., Dardashti, L., Mais, D., Berger, E., Suto, C., McClurg, M. and Heyman, R., 1995, Design of RXR selective agonists. "Retinoids '95" Conference, Nice, France October 8-11.
77. Canon Koch, S.S., Dardashti, L.J., Zhang, L., Badea, B.A., Boehm, M.F., Suto, C.M., Golgman, M.E., Enyeart, D.L., Berger, E., Mais, D.E. and Nadzan, A.M., 1995, Western Biotech Conference, Oct 18-21, San Diego, CA.
78. Canon Koch, S.S., Dardashti, L.J., Zhang, L., Badea, B.A., Boehm, M.F., Suto, C.M., Goldman, M.E., Enyeart, D.L., Berger, E., Mais, D.E. and Nadzan, A.M., 1995, Synthesis of a Potent Class of oxime Retinoid X Receptor Selective Ligands. 209th American Chemical Society National Meeting, Anaheim, CA.
79. Wang, M-W., Crombie, D.L., Mais, D.E., Dinh, B.Q. and Heap, R.B., 1996, Progesterone Imprinting of Postpartum Maternal Behavior. Endocrine Society Meeting, June, San Francisco, CA.
80. Nadzan, A., Boehm, M., Zhang, L., Badea, B., Canon Kock, S., Dardashti, L., White, S., Kallel, A., Mais, D., Berger, E., Suto, C., Gottardis, M., McClurg, M. and Heyman, R., 1996, RXR selective retinoids as potential anticancer agents. 211th American Chemical Society National Meeting, New Orleans, LA.
81. Pollio, G., Wagner, B.L., Breslin, M., Mais, D.E., Cook, C.E., Vedeckis, W.V. and McDonnell, D.P., 1997, Identification of a novel class of antiprogestins which bind with high affinity to the glucocorticoid receptor but exhibit weak antiglucocorticoid activity. Endocrine Society Meeting, June, Minneapolis, MN.
82. Dardashti, L.J., Zhang, L., Boehm, M.F., Flatten, K.S., Berger, E.M., Mais, D.E., Croston, G.E., Nadzan, A.M., and Canon Koch, S.S., 1996, Geometry and RXR Activity of Oxime Retinoids, Maria Goeppert-Mayer Synposium on Chemistry, UCSD, March, San Diego, CA


  1. Takeuchi, K., Kohn, T., Mais, D.E., True, T.A., Wyss, V. and Jakubowski, J.A., 1998, Development of Dual-Acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition: Design, synthesis and evaluation of a novel series of phenyl oxazole derivatives.216th American Chemical Society Meeting, August, Boston, MA




  1. Kohn, T., Jakubowski, J.A., Mais, D.E., True, T., Utterback, B., Wikel, J., Wyss, V. and Takeuchi, K., 1998, Development and SAR of dual-acting TRA/TSI agents, oxazole amide substituted phenyl-(3-pyridylo)-alkenoic acids. 216th American Chemical Society Meeting, August, Boston, MA




  1. Boehm, M.F., Fitzgerald, P., Zou, A., Elgort, M., Bischoff, E., Mere, L., Mais, D.E., Bissonnette, R.P., Heyman, R.A., Nadzan, A.M., Reichman, M. and Allegretto, E.A., 1999, Novel nonsecosteroidal vitamin D3 mimics exert VDR modulating activities in vitro and in vivo with less calcium mobilization than 1,25-dihydroxyvitamin D3. Endocrine Society Meeting, June, San Diego, CA.




  1. Zhang, P., Terefenko, E.A., Zhang, Z., Zhu, Y., Marschke, K. and Mais, D.E., 2000, Synthesis and SAR study of novel 5-aryl benzimidazolinones as progesterone receptor antagonists. XVI International Symposium on Medicinal Chemistry, September, Bologna, Italy.




  1. Michellys, P.Y., Ardecky, R.J., Chen, J.H., Crombie, D.L., Etgen, G., Faul, M., Faulkner, A.L., Grese, T.A., Heyman, R.A., Karanewsky, D.S., Klausing, K., Leibowitz, M.D., Liu, S., Mais, D.E., Mapes, C.M., Marschke, K., Reifel-Miller, A., Ogilvie, K.M., Rungta, D., Thompson, A.W., Tyhonas, J.S. and Boehm, M.F.,

2002, RXR Modulators. New small molecules for Type 2 Diabetes, ACS Meeting, Orlando FL.
88. Mapes, C.M., Ardecky, R.J.,Chen, J.H., Crombie, D.L., Etgen, G., Faul, M., Faulkner, A.L., Grese, T.A., Heyman, R.A.,Karanewsky, Klausing, K., D.S., Leibowitz, M.D., Liu, S., Mais, D.E., Marschke, K., Reifel-Miller, A., Ogilvie, K.M., Rungta, D., Thompson, A.W., Tyhonas, J.S., Boehm, M.F.and Michellys, P.Y., 2003

MISCELLANEOUS

Member of American Astronomical Society


Adjunct Professor of Astronomy at Palomar College, San Marcos Campus
Committee Member of the IAPPP (International Amateur Professional Photoelectric Photometrists)

Articles
1. Mais, D.E., 1995, Observatory Charm in Southern California, Observatory Techniques Magazine, #14, 6-8.
2. Mais, D.E., 1995, CCD Observatory, Observatory Techniques Magazine, #15, 26-27.
3. Mais, D.E., 1996, Adventures in Imaging, Observatory Techniques Magazine, #20, 18-20.
4. Mais, D.E., 1995, Contributing Editor, Making the Transition from Film to CCD Imaging, The Astrograph, Vol. 27 #2, 19-26, 1995.
5. Mais, D.E., 1996, Observatory in Southern California, Amateur Astronomy, 10, 50-52.
6. Mais, D.E., 1995, Contributing Editor, Magazine Reproduction of Digital Images, The Astrograph, Vol. 27 #3, 47, 1995.
7. Mais, D.E., 1995, New Dynamic Image Library, Observatory Techniques Magazine, #16, 28.
8. Mais, D.E., 1996, Observatory Charm in Southern California, Valley Roadrunner (local newspaper), Feb., 7, pg. 18.
9. Mais, D.E., 1996, Upgrading the ST-7 to an ST-8. Observatory Techniques Magazine, #18, 32-33.
10. Mais, D.E., 1996, Riverside Telescope Makers Conference-1996, Observatory Techniques Magazine, #18, 6-8.
11. Mais, D.E., 1996, Riverside Telescope Makers Conference-1996, Amateur Astronomy, 12, 38-43.
12. Mais, D.E., 1996, Astrophotography and Electronic Imaging, Observatory Techniques Magazine, #19, 24-25.
13. Mais, D.E., 1997, RealSky, a Powerful New Database for the Amateur, Observatory Techniques Magazine, #21, 12-13.
14. Mais, D.E., 1997, AstroImage 1996, Observatory Techniques Magazine, #21, 42.
15. Mais, D.E., 1997, Riverside Telescope Makers Conference-1997, Observatory Techniques Magazine, #22, 4-8.
16. Mais, D.E., 1997, Riverside Telescope Makers Conference-1997, Amateur Astronomy, Amateur Astronomy, 16, 36-39.


  1. Mais, D.E., 1997, CCD Travels Beyond the Barrier into Galaxy NGC 891, Observatory Techniques Magazine, #23, 24-25.




  1. Mais, D.E., 1998, AstroImage 1997, Amateur Astronomy, 18, 16.




  1. Mais, D.E., 2001, A New Era in Amateur Astronomical Spectroscopy, International Amateur-Professional Photoelectric Photometry Communications, In Press.




  1. Mais, D.E., 2001, Our Dark Night Skies-Something to be Enjoyed, Valley Center, CA The Roadrunner Newspaper, February 1, A3-4.




  1. Mais, D.E., 2001, Amateur Astronomical Spectroscopy, Amateur Astronomy, 32, 30-32.




  1. Mais, D.E., 2002, Identification of Technetium and unusual 13C levels in C and R type Stars, International Amateur-Professional Photoelectric Photometry Communications, In Press.



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