Consider including your title Prof, Dr, Ms etc as a kindness to those who write to you, but its not essential




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Name


consider including your title – Prof, Dr, Ms etc – as a kindness to those who write to you, but its not essential

Dr. Adam Eyre-Walker

Position

e.g. Reader in Evolutionary Biology,

Royal Society Fellow,

DPhil (John Maynard Smith Scholarship)


Royal Society University Research Fellow

Lab Group


for faculty, list the people that you supervise, in the format:

Albert Einstein (Postdoc)

Ned Kelly (DPhil Student)


Gwenael Piganeau (post-doc)

Nicolas Bierne (post-doc)

Elise Belle (DPhil student)

Megan Woolfit (DPhil student)


Supervisor

for postdocs & students (list all if you have more than one)




Phone

In the format: +44 (0)1273 873 660

Leave blank only if you do not want your number on the website


+44 (0)1273 678480

Office


in the format: BUILDING, room

e.g. BIOLS, 5B16



BIOLS 5B8

Email


a.c.eyre-walker@sussex.ac.uk

Homepage if you already have your own page, give the URL




Research focus in the following format(text can be in the form of a list or bullet points if you like):


Short title (≤10words) The rates and effects of mutations

Brief user-friendly description (≤ 100 words).


Mutations are the ultimate source of all genetic variation but until recently we had few estimates of how frequently mutations occurred or what their effects were. We have been addressing both of these problems using DNA sequence data. We have recently estimated minimum rates of harmful mutation in a range of animal species, including our own. We have also been attempting to estimate the rate of adaptive amino acid substitution and the proportion of mutations which are slightly deleterious.




Research Focus 2: The Evolution of Isochores

Base composition varies along mammalian chromosomes over very large scales of hundreds of kilobases. This structure has been called the isochore structure of the genome. The origins of this structure remain unclear. It has been suggested that it might be a consequence of neutral processes, either mutation bias or biased gene conversion, or natural selection. We have been using a variety of approaches to test whether the structure is being actively maintained, and if it is, what process is responsible for its maintainence.



Research Focus 3: Recombination in mitochondria

It is generally thought that mitochondria are solely inherited from one parent, usually the male, in higher plants and animals, and that mtDNA is clonally inherited without recombination. We have been attempting to test whether recombination occurs in mtDNA in a variety of animals, including humans.


Teaching


Courses you teach at Sussex, in the format: Course name (your role) Course URL

e.g. Topics in Evolutionary Theory (co-ordinator)



http://www.biols.susx.ac.uk/ugteach/course/topet.htm

Evolution 1 (tutor) http://www.biols.susx.ac.uk/ugteach/course/evol1.htm

Molecular Ecology and Evolution



Selected publications: include only your top ten (or less) here – choose the ones you are most proud of, or that show your research interests best. Publications should be in this format (see below for more details):


Surname Initial, Surname Initial (Year) Title. Journal Volume:Pages [file.pdf]

Include the pdf file name in square brackets only if you are able to provide a pdf file of this publication for people to download- see below for details.

Smith, NGC, Eyre-Walker A (2003) Partitioning the variation in mammalian substitution rates. Molecular Biology and Evolution (in press)
Eyre-Walker A, Keightley PD, Smith NGC, Gaffney D (2002) Quantifying the slightly deleterious model of molecular evolution. Molecular Biology and Evolution (in press)
Smith NGC, Eyre-Walker A (2002) Adaptive protein evolution in Drosophila. Nature 415:1022-1024 [SmithNature02.pdf]
Belle EMS, Eyre-Walker A (2002) A test of whether selection maintains isochores using sites polymorphic for Alu and L1 elements. Genetics 160:815-817 [BelleGenetics02.pdf]
Smith NGC, Eyre-Walker A (2001) Synonymous codon bias is not caused by mutation bias in G+C rich genes in humans. Molecular Biology and Evolution 18:982-986 [SmithMBE01iso.pdf]
Keightley PD, Eyre-Walker A (2000) Deleterious mutations and the evolution of sex. Science 290: 331-333 [KeightleyScience00.pdf]
Awadalla P, Eyre-Walker A., Maynard Smith J. (1999) Linkage disequilibrium and recombination in hominid mitochondrial DNA. Science 286: 2524-2525 [AwadallaScience99.pdf]
Eyre-Walker A, Keightley PD (1999) High genomic deleterious mutation rates in hominids. Nature 397: 344-347 [EWNature99.pdf]
Eyre-Walker A (1998) Problems with parsimony in sequences of biased base composition. Journal of Molecular Evolution 47: 686-690 [EWJME98.pdf]
Eyre-Walker A (1993). Recombination and genome evolution in mammals. Proceedings of the Royal Society Series B. 252: 237-243 [EW.PRS93.pdf]


Complete publication list

This is optional, but you can include every last obscure conference proceeding if you like, following citation style described below. NB if you have included all of your publications above leave this box blank

Eyre-Walker A (2003) Changing effective population size and the McDonald-Kreitman test. Genetics (in press)
Smith NGC, Eyre-Walker A (2003) Partitioning the variation in mammalian substitution rates. Molecular Biology and Evolution (in press)
Eyre-Walker A, Keightley PD, Smith NGC, Gaffney D (2002) Quantifying the slightly deleterious model of molecular evolution. Molecular Biology and Evolution (in press)
Belle EMS, Eyre-Walker A (2002) Analysis of the phylogenetic distribution of isochores in vertebrates and a test of the thermal stability hypothesis. Journal of Molecular Evolution. 55: 356-363
Belle EMS, Eyre-Walker A (2002) A test of whether selection maintains isochores using sites polymorphic for Alu and L1 elements. Genetics 160: 815-817 [BelleGenetics02.pdf]
Smith NGC, Eyre-Walker A (2002) Adaptive protein evolution in Drosophila. Nature 415: 1022-1024 [SmithNature02.pdf]
Smith NGC, Eyre-Walker A (2002) The compositional evolution of the murid genome. Journal of Molecular Evolution 55: 197-201 [SmithJME02.pdf]
Eyre-Walker A (2002) Codon Usage Bias. Encyclopedia of Evolution.
Eyre-Walker A, Hurst LD (2001) The evolution of isochores. Nature Reviews Genetics 2: 549-555 [EWNRG01.pdf]
Eyre-Walker A, Awadalla P (2001) Does human mtDNA recombine? Journal of Molecular Evolution 53: 430-435 [EWJME01.pdf]
Keightley PD, Eyre-Walker A (2001) Response to Kondrashov : Sex and U. Trends in Genetics 17: 77-78 [KeightleyTIG01.pdf]
Eyre-Walker A (2001) Base composition patterns. Encyclopedia of Life Sciences.
Meunier J, Eyre-Walker A (2001) The Correlation between Linkage Disequilibrium and Distance. Implications for Recombination in Hominid Mitochondria. Molecular Biology and Evolution 18: 2127-2131 [MeunierJME01.pdf]
Smith NGC, Eyre-Walker A (2001) Nucleotide Substitution Rate Estimation in Enterobacteria: Approximate and Maximum-Likelihood Methods Lead to Similar Conclusions Molecular Biology and Evolution 18: 2124-2126 [SmithMBE01ecoli.pdf]
Smith NGC, Eyre-Walker A (2001) Why are translationally sub-optimal synonymous codons used in Escherichia coli ? Journal of Molecular Evolution 53: 225-236 [SmithJME01syn.pdf]
Smith NGC, Eyre-Walker A. (2001) A test of amino acid reversibility. Journal of Molecular Evolution 52: 467-469 [SmithJME01amino.pdf]
Smith NGC, Eyre-Walker A (2001) Synonymous codon bias is not caused by mutation bias in G+C rich genes in humans. Molecular Biology and Evolution 18: 982-986 [SmithMBE01iso.pdf]
Keightley PD, Eyre-Walker A (2000) Deleterious mutations and the evolution of sex. Science 290: 331-333 [KeightleyScience00.pdf]
Eyre-Walker A (2000) Do mitochondria recombine in humans? Philosophical Transactions of the Royal Society Series B. 355: 1573-1580 [EWPTRS00.pdf]
Awadalla P, Eyre-Walker A, Maynard Smith J (2000) Questioning evidence for recombination in human mitochondrial DNA. Science 288: 1931a [AwadallaScience00.pdf]
Hurst LD, Eyre-Walker A (2000) Reading the bands. Bioessays 22: 105-107
Eyre-Walker A, Smith NH, Maynard Smith J (1999) Reply to Macaulay et al. (1999): mtDNA recombination – reasons to panic. Proceedings of the Royal Society Series B. 266: 2041-2042 [EWPRS99b]
Keightley PD, Eyre-Walker A (1999) Terumi Mukai and the riddle of deleterious mutation rates. Genetics 153: 515-523 [KeightleyGenetics99.pdf]
Awadalla P, Eyre-Walker A, Maynard Smith J (1999) Linkage disequilibrium and recombination in hominid mitochondrial DNA. Science 286: 2524-2525 [AwadallaScience99.pdf]
Eyre-Walker A (1999) Evidence of selection on silent site base composition in mammals: potential implications for the evolution of isochores and junk DNA. Genetics 152: 675-683 [EWGenetics99.pdf]
Eyre-Walker A, Keightley PD (1999) High genomic deleterious mutation rates in hominids. Nature 397: 344-347 [EWNature99.pdf]
Eyre-Walker A, Smith NH, Maynard Smith J (1999) How clonal are human mitochondria? Proceedings of the Royal Society Series B. 266: 477-483 [EWPRS99a.pdf]
Eyre-Walker A (1998) Problems with parsimony in sequences of biased base composition. Journal of Molecular Evolution 47: 686-690 [EWJME98.pdf]
Kliman RM, Eyre-Walker A (1998) Patterns of base composition within Drosophila genes. Journal of Molecular Evolution 46:534-541 [KlimanJME98.pdf]
Eyre-Walker A, Gaut RL, Hilton H, Feldman DL, Gaut BG (1998) Investigation of the bottleneck leading to the domestication of maize, using the coalescent. Proceedings of the National Academy of Sciences USA 95: 4441-4446 [EWPNAS98.pdf]
Akashi H, Eyre-Walker A (1998) Translational selection and molecular evolution. Current Opinions in Genetic Development Bioliogy 8: 688-693
Akashi H, Kliman RM, Eyre-Walker A (1998) Mutation pressure, natural selection and the evolution of base composition in Drosophila. Genetica 103: 49-60
Peck JR, Eyre-Walker A (1997) The Muddle about mutations. Nature 387:135-136
Eyre-Walker A (1997) Differentiating between selection and mutation bias. Genetics 147: 1983-1987 [EWGenetics97.pdf]
Eyre-Walker A, Gaut BG (1997) Correlated rates of synonymous site evolution across plant genomes. Molecular Biology and Evolution 14: 455-460 [EWMBE97.pdf]
Eyre-Walker A (1996) Synonymous codon bias is related to gene length in Escherichia coli: evidence of selection for translational accuracy? Molecular Biology and Evolution 13: 864-872 [EWMBE96.pdf]
Eyre-Walker A (1996) The close proximity of Escherichia coli genes: implications for stop codon and synonymous codon use. Journal of Molecular Evolution 42: 73-78
Eyre-Walker A, Bulmer M (1995) Synonymous substitution rates in enterobacteria. Genetics 140: 1407-1412 [EWGenetics95.pdf]
Eyre-Walker A (1995) The distance between Escherichia coli genes is related to the level of gene expression. Journal of Bacteriology 177: 5368-5369
Eyre-Walker A (1995) Does very short patch (VSP) repair efficiency vary in relation to gene expression level? Journal of Molecular Evolution 40:705-706
Eyre-Walker A (1994). DNA mismatch repair and synonymous codon evolution in mammals. Molecular Biology and Evolution 11: 88-98 [EWMBE94.pdf]
Eyre-Walker A (1994) Synonymous substitutions are clustered in enterobacterial genes. Journal of Molecular Evolution 39: 448-451
Eyre-Walker A (1993). Recombination and genome evolution in mammals. Proceedings of the Royal Society Series B. 252: 237-243
Eyre-Walker A, Bulmer M (1993) Reduced synonymous substitution rate at the start of enterobacterial genes. Nucleic Acids Research 21: 4599-4603
Eyre-Walker A (1992) The role of DNA replication and isochores in generating mutation and silent substitution rate variance in mammals. Genetical Research 60: 61-67
Eyre-Walker A (1992) Evidence that both G+C rich and G+C poor isochores replicate early and late in the cell cycle. Nucleic Acids Research 20: 1497-1501
Eyre-Walker A (1992) The effect of constraint on the rate of evolution in neutral models with biased mutation. Genetics 131: 233-234 [EWGenetics92.pdf]
Eyre-Walker A (1991) An analysis of codon usage in mammals: selection or mutation bias? Journal of Molecular Evolution 33: 442-449
Eyre-Walker A (1990) A recombination. Nature 345: 673





Picture: attach file and write name here in the format: YourSurname.webpic.format

e.g. Belle.webpic.jpg

EEW.webpic.jpg


Picture


You MUST include a picture for your webpage. You can choose anything, but here are some suggestions:

1. a picture of you

2. a picture of your lab group, your study animal, or some such work related thing

3. a picture of something is part of your life - your garden, your favourite ecosystem, whatever.

Preferred format: jpeg
Format for listing publications.

All publications should be listed in a standard format as follows:

Surname Initial, Surname Initial (Year) Title. Journal Volume:Pages
Note that it has no bold or italics or any other fancy formatting (except italics for species names etc). If you use Endnote, export as Journal of Molecular Evolution format. It has been requested that we include full journal titles, but if this is a problem, then use abbreviations.
Here are examples for journal articles, books, book chapter.

Bromham L, Clark F, McKee JJ (2001) Discovery of a novel murine type C retrovirus by datamining. Journal of Virology 75:3053-3057 [Bromham.JME96.pdf]


Sowls L (1984) The peccaries. University of Arizona Press, Tucson, Arizona
Fuller MT (1993) Spermatogenesis. In: Bate M, Arias AM (eds) The development of Drosophila melanogaster. Cold Spring Harbour Laboratory Press, Cold Spring Harbour, NY, p 71 - 147

pdf downloads of your publications

this is optional, but you are encouraged to include pdf files of as many of your top ten publications as possible for people to download. This makes your best work easily accessible to anyone who is interested. Don’t ask me about the copyright implications because I havent a clue.


Please send publications (in pdf format only) with your datasheet and photo to Noel (noel@sussex.ac.uk) with the file name format:

YourSurname.JournalYear.pdf.



e.g. Bromham.JME96.pdf, Woolfit.Evol02.pdf.

You need to follow this naming convention if we are to make sense of all the files.


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