College of Pharmacy Final Exam Date: 14/6/1429 H




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King Saud University PHG. 454 Dr. Ali El-Gamal

College of Pharmacy Final Exam Date: 14/6/1429 H


Pharmacognosy Dept.

Student’s Name …………………………..……. No……………


الأسئلة موزعة على سبع صفحات




Answer the following questions:-


Question No. I

Fill in the blank spaces
1- Dihydrocodeine, heroin and ethyl morphine are belonging to………………,while ……………………,………………..and ……………………are belonging to opioids.
2- The presence of 3AM in heroin sample in generally attributed to………………., while the presence of 6AM in generally attributed to………………..
3- …………………….is probably the method of choice for quantification of opium and morphine sample.
4- From a forensic point of view, anion testing is applicable to all opiate samples except………….…….and…………………….
5-Salt of morphine hydrochloride can be detected by……………..reagent, while the sulphate salt can be detected by using …………………….reagent.
6- Poppy seeds are used for ………………..,………………..

and…………………………………..
7- The morphine content in granulated opium is adjusted to pharmacopoeial constants by addition of…….………………..

and/or …………………
8- Opium and opiates are belonging to CNS……………..drugs.
9- Pin-point pupil is one of sign and symptom of ……………...
10- Opium and opiates are used as………..………………and for treatment of …………………
11- HPLC with ……………………detector used for detection of heroin and related alkaloids.

Question No. II

Mark (√) for the correct sentences and (X) for the wrong one.
1- High potential for abuse and no accepted medicinal use of LSD let it classified as Schedule II substances ( )
2- Lysergide like most of hallucinogens is almost always administered subcutaneously ( )
3- LSD absorbed rapidly from GIT with selective distribution or concentration in the brain ( ).
4- The margin for safety between effective & toxic doses in lysergide is extremely high ( ).
5- The detection limit of fluorescence test for lysergide is more than 1g. ( ).
6- Chromatographic methods, like CC or TLC can use for analysis of lysergide from isolysergide ( ).
7- Marked variation in heroin contents and contaminants could indicate the rout of administration ( ).
8-Diamorphine is more potent and less addict than

morphine( ).
9- Color test is one of the methods used for differentiation between morphine and heroin ( ).
10- Positive meconic acid test, positive porphyroxine and presence of plant fragments indicating the presence of opium dross ( ).
Question No. III

Account for each of the following:


  1. Replacement of lysergide by phencyclidine



2- Conversion of lysergide to taratrate salt.


3- Diamorphine is belonging to internationally controlled narcotic analgesic with morphine, codeine and other synthethetic opiate drugs.


  1. Fluorescence test is essential test for identification of lysergide.



5- Absence of plant fragment from concentrated opium

Question No. IV

Short account on each of the following:

1- Ergotism
2- TLC condition for analysis of lysergide (type of adsorbent, solvent system and methods of detection).

3- Progress in the development of dosage forms of illicit lysergide
4- Two clandestine methods for production of lysergide

5- Procedure for illicit production of opium from poppy capsule.


6- HPLC condition for analysis of opium and morphine (Adsorbent, mobile phase and detection method)
7- Pantopan
8- Four differences between heroin & morphine.

9- Rout of administration of opium and heroin.

10- Sympathetic & parasympathetic effects of withdrawal or abstinence syndrome for opium and opiates.

Question No. V

The following structures represent different important classes of drug abused from forensic point of view, please answer the following:



  1. Identify each compound


  1. Main class of each one related to different classes of drug abused



  1. Test for compound A



  1. Use of A & B


  1. Dangerous of use A & C


  1. Test for suspected material containing D


  1. Natural source of E



  1. Two methods used for detection of E when it is mixed with wheat flour or on TLC (spray reagent)







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