Virus Cohort 1 (104 tcid50)




Дата канвертавання19.04.2016
Памер16.19 Kb.
Table 2: Geometric mean titers (GMT) and geometric mean fold rises (GMFR) in serum antibodies

Virus

Cohort 1 (104 TCID50)

Cohort 2 (105 TCID50)

Cohort 3 (106 TCID50)

MEDI-534

N=19

Placebo

N=21

MEDI-534

N=21

Placebo

N=19

MEDI-534

N=20

Placebo

N=20

RSV*

Day 0



















GMT (95% CI)

42.00 (25.6, 69.8)

49.19 (32.3, 74.9)

68.42 (47.3, 95.7)

50.86 (34.8, 74.0)

52.99 (33.7, 84.5)

52.93 (32.9, 83.2)

Day 28-35



















GMT (95% CI)

40.75 (25.7, 66.9)

42.86 (29.5, 62.8)

61.55 (43.3, 88.3)

48.04 (32.2, 70.7)

66.92 (41.4, 109.2)

53.27 (32.8, 85.8)

GMFR

0.93 (0.7, 1.5)

0.87 (0.7, 1.0)

0.93 (0.8, 1.1)

0.94 (0.8, 1.1)

1.26 (0.9, 2.1)

1.02 (0.9, 1.2)

hPIV3§

Day 0



















GMT (95% CI)

114.04 (66.5, 198.3)

89.03 (54.3, 146.1)

112.17 (68.4, 178.1)

112.17 (68.4, 178.1)

137.19 (76.1, 247.3)

148.11 (93.9, 246.3)

Day 28-35



















GMT (95% CI)

118.99 (79.7, 184.4)

83.34 (49.1, 136.7)

103.97 (66.3, 157.6)

103.97 (66.3, 157.6)

123.64 (71.0, 207.9)

187.40 (115.4, 304.4)

GMFR

1.08 (0.9, 1.3)

0.94 (0.8, 1.0)

1.04 (0.9, 1.2)

1.04 (0.9, 1.2)

0.90 (0.8, 1.1)

1.29 (1.0, 1.8)

* neutralization assay; results are the mean of replicate 1 and replicate 2; § hemagglutination inhibition (HAI) assay; † for titer reported as <20, a value of 10 was assigned when computing GMT; ‡ GMFR is the geometric mean of the ratios of post-dose antibody to the pre-dose antibody


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