Symbol Description log2 change




Дата канвертавання22.04.2016
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SI table 1: Transcripts with decreased abundance in the striatum of SrfD1Cre mice.


Probe

Symbol

Description

log2 change

1418255_s_at

Srf

serum response factor

-1.97

1449425_at

Wnt2

wingless-related MMTV integration site 2

-1.61

1423258_at

Syt9

synaptotagmin IX

-1.37

1452624_at

Ctnna2

catenin (cadherin associated protein), alpha 2

-1.36

424150_at

Gdpd5

glycerophosphodiester phosphodiesterase domain containing 5

-1.34

1423640_at

Synpr

synaptoporin

-1.27

1420667_at

Doc2b

double C2, beta

-1.25

1455883_a_at

Lrrtm1

leucine rich repeat transmembrane neuronal 1

-1.25

1415779_s_at

Actg1

actin, gamma, cytoplasmic 1

-1.23

1427618_at

Cdh9

cadherin 9

-1.22

1427054_s_at

Abi3bp

ABI gene family, member 3 (NESH) binding protein

-1.21

AFFX-b-ActinMur/M12481_5_at

Actb

actin, beta, cytoplasmic

-1.20

1422053_at

Inhba

inhibin beta-A

-1.20

1423049_a_at

Tpm1

tropomyosin 1, alpha

-1.17

1439332_at

Ddit4l

DNA-damage-inducible transcript 4-like

-1.15

1426677_at

Flna

filamin, alpha

-1.10

1420377_at

St8sia2

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2

-1.08

1422649_at

Cntn6

contactin 6

-1.04

1455298_at







-1.02

1450700_at

Cdc42ep3

CDC42 effector protein (Rho GTPase binding) 3

-1.01

1427306_at

Ryr1

ryanodine receptor 1, skeletal muscle

-0.99

1455758_at

Prkcc

protein kinase C, gamma

-0.97

1460300_a_at

Ltk

leukocyte tyrosine kinase

-0.91

1430826_s_at

Gcnt2

glucosaminyl (N-acetyl) transferase 2, I-branching enzyme

-0.87

1422335_at

Adra2c

adrenergic receptor, alpha 2c

-0.87

1450839_at

D0H4S114

DNA segment, human D4S114

-0.86

1418304_at

Pcdh21

protocadherin 21

-0.86

1451469_at

D530005L17Rik

RIKEN cDNA D530005L17 gene

-0.85

1427975_at

2210403B10Rik

RIKEN cDNA 2210403B10 gene

-0.85

1421436_at

Grid2

glutamate receptor, ionotropic, delta 2

-0.82

1422438_at

Ephx1

epoxide hydrolase 1, microsomal

-0.82

1448738_at

Calb1

calbindin-28K

-0.81

1417575_at

Otub2

OTU domain, ubiquitin aldehyde binding 2

-0.80

1419517_at

Cnih3

cornichon homolog 3 (Drosophila)

-0.80

1435865_at

Hist3h2a

histone 3, H2a

-0.80

1422673_at

Prkcm

protein kinase C, mu

-0.79

1422977_at

Gp1bb

glycoprotein Ib, beta polypeptide

-0.78

1418881_at

Efcbp2

EF hand calcium binding protein 2

-0.78

1423757_x_at

Igfbp4

insulin-like growth factor binding protein 4

-0.77

1418412_at

Tpd52l1

tumor protein D52-like 1

-0.76

1416776_at

Crym

crystallin, mu

-0.75

1418710_at

Cd59a

CD59a antigen

-0.73

1415818_at

Anxa6

annexin A6

-0.73

1416627_at

Spint1

serine protease inhibitor, Kunitz type 1

-0.73

1452333_at

Smarca2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

-0.73

1423690_s_at

Gpsm1

G-protein signalling modulator 1 (AGS3-like, C. elegans)

-0.72

1449575_a_at

Gstp1

glutathione S-transferase, pi 1

-0.71

1426454_at

Arhgdib

Rho, GDP dissociation inhibitor (GDI) beta

-0.71

1428891_at

9130213B05Rik

RIKEN cDNA 9130213B05 gene

-0.70

1424771_at

H2afj

H2A histone family, member J

-0.70

1434881_s_at

Kctd12

potassium channel tetramerisation domain containing 12

-0.70

1450928_at

Id4

inhibitor of DNA binding 4

-0.69

1416242_at

Klhl13

kelch-like 13 (Drosophila)

-0.68

1420977_at

Man1a2

mannosidase, alpha, class 1A, member 2

-0.67

1428052_a_at

Zmym1

zinc finger, MYM domain containing 1

-0.66

1448523_at

Nphp1

nephronophthisis 1 (juvenile) homolog (human)

-0.66

1454656_at

Spata13

spermatogenesis associated 13

-0.65

1417111_at

Man1a

mannosidase 1, alpha

-0.65

1424852_at

Mef2c

myocyte enhancer factor 2C

-0.64

1416156_at

Vcl

vinculin

-0.64

1423894_a_at

Dalrd3

DALR anticodon binding domain containing 3

-0.63

1448554_s_at

Myh7

myosin, heavy polypeptide 7, cardiac muscle, beta

-0.62

1460444_at

Arrb1

arrestin, beta 1

-0.62

1454086_a_at

Lmo2

LIM domain only 2

-0.62

1448684_at

Ppp1r2

protein phosphatase 1, regulatory (inhibitor) subunit 2

-0.62

1423853_at

6330527O06Rik

RIKEN cDNA 6330527O06 gene

-0.61

1423054_at

Wdr1

WD repeat domain 1

-0.61

1449348_at

Mpp6

membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)

-0.61

1418588_at

Nrsn1

neurensin 1

-0.61

1420437_at

Indo

indoleamine-pyrrole 2,3 dioxygenase

-0.60

1423505_at

Tagln

transgelin

-0.60

1419247_at

Rgs2

regulator of G-protein signaling 2

-0.59


SI table 2: Transcripts with increased abundance in the striatum of SrfD1Cre mice.

Probe

Symbol

Description

log2 change

1427351_s_at

Igh-6

immunoglobulin heavy chain 6 (heavy chain of IgM)

3.29

1416266_at

Pdyn

prodynorphin

2.10

1426734_at

BC022623

cDNA sequence BC022623

1.88

1452135_at

Gpx6

glutathione peroxidase 6

1.77

1423267_s_at

Itga5

integrin alpha 5 (fibronectin receptor alpha)

1.69

1421262_at

Lipg

lipase, endothelial

1.65

1421821_at

Ldlr

low density lipoprotein receptor

1.47

1418817_at

Chmp1b

chromatin modifying protein 1B

1.42

1451917_a_at

Dcamkl1

doublecortin and calcium/calmodulin-dependent protein kinase-like 1

1.41

1422583_at

Rab3b

RAB3B, member RAS oncogene family

1.40

1423269_a_at

Nedd4l

neural precursor cell expressed, developmentally down-regulated gene 4-like

1.36

1416505_at

Nr4a1

nuclear receptor subfamily 4, group A, member 1

1.32

1428781_at

Dmkn

dermokine

1.31

1426509_s_at

Gfap

glial fibrillary acidic protein

1.26

1423311_s_at

Tpbg

trophoblast glycoprotein

1.23

1422538_at

Extl2

exotoses (multiple)-like 2

1.16

1417810_a_at

Pacsin2

protein kinase C and casein kinase substrate in neurons 2

1.15

1423186_at

Tiam2

T-cell lymphoma invasion and metastasis 2

1.02

1420146_at

Tfb1m

transcription factor B1, mitochondrial

1.00

1423860_at

Ptgds

prostaglandin D2 synthase (brain)

1.00

1443969_at

Irs2

insulin receptor substrate 2

0.99

1418782_at

Rxrg

retinoid X receptor gamma

0.93

1451386_at

Blvrb

biliverdin reductase B (flavin reductase (NADPH))

0.90

1427229_at

Hmgcr

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

0.88

1427779_a_at

Cd4

CD4 antigen

0.88

1426106_a_at

Syt6

synaptotagmin VI

0.87

1417929_at

Slc7a8

solute carrier family 7 (cationic amino acid transporter, y+ system), member 8

0.87

1450243_a_at

Dscr1l1

Down syndrome critical region gene 1-like 1

0.80

1423078_a_at

Sc4mol

sterol-C4-methyl oxidase-like

0.80

1459903_at

Sema7a

sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A

0.79

1421735_a_at

St8sia5

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5

0.78

1427900_at

Pip5kl1

phosphatidylinositol-4-phosphate 5-kinase-like 1

0.75

1432432_a_at

Rab3c

RAB3C, member RAS oncogene family

0.73

1424831_at

Cpne2

copine II

0.73

1423506_a_at

Nnat

neuronatin

0.72

1448280_at

Syp

synaptophysin

0.70

1448619_at

Dhcr7

7-dehydrocholesterol reductase

0.69

1427523_at

Six3

sine oculis-related homeobox 3 homolog (Drosophila)

0.69

1421093_at

Slc7a10

solute carrier family 7 (cationic amino acid transporter, y+ system), member 10

0.68

1429240_at

Stard4

StAR-related lipid transfer (START) domain containing 4

0.68

1421943_at

Tgfa

transforming growth factor alpha

0.68

1418021_at

C4b

complement component 4B (Childo blood group)

0.66

1419425_at

Cnr1

cannabinoid receptor 1 (brain)

0.66

1422533_at

Cyp51

cytochrome P450, family 51

0.65

1425006_a_at

Vrk1

vaccinia related kinase 1

0.65

1416623_at

Thbs3

thrombospondin 3

0.63

1452082_at

6430548M08Rik

RIKEN cDNA 6430548M08 gene

0.62

1456395_at

Ppargc1a

peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

0.62

1431936_a_at

Neu2

neuraminidase 2

0.62

1421176_at

Rasgrp1

RAS guanyl releasing protein 1

0.60

1460257_a_at

Mthfs

5, 10-methenyltetrahydrofolate synthetase

0.60

1424191_a_at

Tmem41a

transmembrane protein 41a

0.60

1460327_at

Gpr88

G-protein coupled receptor 88

0.59

1419221_a_at

Rgs14

regulator of G-protein signaling 14

0.59


SI table 3: Transcripts induced by cocaine treatment.










log2 change

Probeset

Symbol

Description

ctrl

SrfD1Cre

1423100_at

Fos

FBJ osteosarcoma oncogene

4.21

3.6

1427682_a_at

Egr2

early growth response 2

3.9

-0.1

1418687_at

Arc

activity regulated cytoskeletal-associated protein

3.6

2.7

1416505_at

Nr4a1

nuclear receptor subfamily 4, group A, member 1

2.9

2.3

1449977_at

Egr4

early growth response 4

2.8

0.0

1415899_at

Junb

Jun-B oncogene

2.8

2.9

1426721_s_at

Tiparp

TCDD-inducible poly(ADP-ribose) polymerase

2.6

3.0

1448830_at

Dusp1

dual specificity phosphatase 1

2.3

2.5

1422134_at

Fosb

FBJ osteosarcoma oncogene B

2.2

2.9

1416250_at

Btg2

B-cell translocation gene 2, anti-proliferative

2.0

1.1

1450971_at

Gadd45b

growth arrest and DNA-damage-inducible 45 beta

1.9

2.2

1417406_at

Sertad1

SERTA domain containing 1

1.6

1.7

1415834_at

Dusp6

dual specificity phosphatase 6

1.6

1.3

1451264_at

Frmd6

FERM domain containing 6

1.6

1.8

1418025_at

Bhlhb2

basic helix-loop-helix domain containing, class B2

1.5

1.1

1449188_at

Midn

midnolin

1.4

1.1

1417065_at

Egr1

early growth response 1

1.3

0.6

1455271_at

LOC620695




1.3

1.3

1423294_at

Mest

mesoderm specific transcript

1.3

2.1

1449851_at

Per1

period homolog 1 (Drosophila)

1.2

1.3

1416700_at

Rnd3

Rho family GTPase 3

1.2

0.5

1443969_at

Irs2

insulin receptor substrate 2

1.2

1.1

1460275_at

Gpr3

G-protein coupled receptor 3

1.1

1.7

1421962_at

Dnajb5

DnaJ (Hsp40) homolog, subfamily B, member 5

1.0

0.9

1437696_at

BC049807

cDNA sequence BC049807

1.0

2.0

1424735_at

Slc25a25

solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25

1.0

1.6

1419247_at

Rgs2

regulator of G-protein signaling 2

0.8

0.5

1425131_at

Ptpn5

protein tyrosine phosphatase, non-receptor type 5

0.8

1.0

1423852_at

Tmem46

transmembrane protein 46

0.8

0.2

1438011_at

Pcyt1a

phosphate cytidylyltransferase 1, choline, alpha isoform

0.7

0.4

1427359_at

A630082K20Rik

RIKEN cDNA A630082K20 gene

0.7

1.3

1418817_at

Chmp1b

chromatin modifying protein 1B

0.7

0.6

1418250_at

Arfl4

ADP-ribosylation factor 4-like

0.7

0.3

1418349_at

Hbegf

heparin-binding EGF-like growth factor

0.7

0.4

1451027_at

Baiap2

brain-specific angiogenesis inhibitor 1-associated protein 2

0.6

1.0

1460565_at

Slc41a1

solute carrier family 41, member 1

0.6

0.5

1417930_at

Nab2

Ngfi-A binding protein 2

0.6

0.4

1418007_at

1810007M14Rik

RIKEN cDNA 1810007M14 gene

0.6

1.0

1Values in bold indicate a significance of p<0.001.





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