3. Adding new species/strains/types to approved protocol Complete the relevant section(s) applicable.
Attach Procedure C form if the new species/strains are genetically modified animals and the source is not from your own breeding protocol.
1. Removing species/strains/types from the study
1.1 Name the species/strains/types to be deleted: 1.2 Explain why the change is required:
2. Replacing the species/strains/types of approved protocol
2.1 Identify the new species/strains/types required and the species/strains/types to be replaced. Attach Procedure C form if the new species/strains are genetically modified animals and the source is not from your own breeding protocol.
2.2 Explain why the change is required and justify the choice of the new species/strains/types.
2.3 Will there be any change in the approved animal numbers? Yes. Some of the approved species/strains/types have been used. Complete Appendix 2
No. Animals to be replaced have not been used (or provide explanation below):
2.4 Continue to complete Section 4 below. 3. Adding new species/strains/types to approved protocol 3.1 Name the new species/strains/types to be added (please use proper nomenclature). Complete Appendix 2 for the number of animals that will be used for each species / strain / type. Attach Procedure C form if the new species/strains are genetically modified animals and the source is not from your own breeding protocol.
3.2 Explain why the new species/strains/types are required.
3.3 Will there be any change in procedure? Yes. Please complete Appendix 3
No. Please answer the following: If you are adding new species/strains/types without changing the procedure, please justify the need to conduct the same experiment in multiple species/strains/types.
3.4 Continue to complete Section 4 below. 4. Scientific justification and other information for new species / strains / types requested 4.1 Is there any change in the animal housing and use location? Yes. Please complete Appendix 5.
No. Please indicate the housing location: 4.2 Source of animals Please note that CM and/or IACUC have to be informed prior to any movement of animals into or out of NUS, including research laboratories (e.g., importation, transfer from another institution, delivery by local suppliers to the labs, etc). Sources obtained through CM. Species/strains:
My own approved breeding protocol No: Species/stains:
Other PI’s approved breeding protocol No: Species/stains:
Other sources obtained directly by PI. (Only for species caught from the wild by researches. All laboratory animals including fish and frog should be obtained through CM) Please indicate the species/strains and source, including the names and addresses of the suppliers, if applicable:
4.3 Describe other features of the species (e.g., anatomic, physiologic, genetic, etc) that make it desirable for this model.
5. Occupational Health and Safety Please note that OSHE requires Principal Investigator to submitan Amendment to Risk Assessment if there are significant changes in the protocol, practices, material, personnel or environment that would require additional risk controls. 5.1 Have you submitted an amendment of risk assessment to OSHE for the above changes in animal species / strains / type?
Yes, approved. The approved Risk Assessment Amendment number (e.g., FOXo-123R1) is: Yes, submitted. The amendment of the approved Risk Assessment (No: ) has been submitted to OSHE. .
No, amendment of the Risk Assessment is not required. Please explain: