Curriculum vitae name: Cheng, Yuan-Bin Working Address




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CURRICULUM VITAE

Name: Cheng, Yuan-Bin

Working Address: Kaplan Lab 8645, Discovery way, La Jolla, CA, 92037.

Home Address: No.93, 2F, Jing-An St. Taipei county, 235, Taiwan, Republic of China.

E-mail: jmb0709@hotmail.com

Phone: 886-02-2245-6352

Mobile phone: 858-345-0879

Date of Birth: July 9, 1979

Nationality: Taiwan

Marital Status: Single
Employment:
Post-Doctoral Fellow in Center for Marine Biotechnology and Biomedicine, Center for Marine Science, University of North Carolina Wilmington (September 2011 – August 2012)
Post-Doctoral Fellow in Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego (August 2010 – August 2011)
Post-Doctoral Fellow in School of Pharmacy, College of Medicine, National Taiwan University (June 2008 – July 2010)
Academic Qualifications:


  1. Ph. D in Marine Biotechnology and Resources, College of Marine Sciences, Sun Yat-sen University, Taiwan (2002-2007)

  2. M. Sc in Marine Biotechnology and Resources, College of Marine Sciences, Sun Yat-sen University, Taiwan (2001-2002)

  3. B. Sc in Chemistry, College of Life Science, Kaohsiung medicinal University, Taiwan (1997-2001)


Research Interest:
I am interested in the isolation and characterization of natural products from both terrestrial and marine organisms in particular diterpenoids, lignans, triterpenoids, steroids, alkaloids, etc. In addition, I am also interested in modifying bioactive lead compounds and studying the Structure-Activity Relationship.
Topics of Research:
Phytochemistry – Isolation, purification and structural elucidation of secondary metabolites from traditional Chinese medicines (Kadsura, Schisandra, Illicium) and potential anti-cancer plants (Taxus, Casearia, Hypercium).

Marine Invertebrates Natural Product Chemistry research of secondary metabolites from marine invertebrates, such as soft corals (Clavularia, Xenia, Cespitularia, Sarcophyton) and sponges (Xestospongia).

Marine Microorganisms – actinomycine and dinoflagellate
Working techniques
1. Spectrometers of LC-Mass, IR, UV, CD, optical rotation

2. Bruker and Varian NMR operation and application to structural elucidation (served as a NMR supervisor in the Institute of Marine Biotechnology and Resources)

3. HPLC operation (Hitachi, Shimadzu, HP, Waters)

4. Computer skills including MS-Word, MS-PowerPoint, Xwin-NMR, ChemDraw, MestReNova


Summary of Research:
Title of Ph. D Thesis: Studies on the Natural Products from the Taiwanese Soft Corals Clavularia viridis, Xenia florida, Cespitularia taeniata, Cespitularia hypotentaculata, and Sarcophyton stolidotum


  • Isolation of eight new and seven known prostanoids from Clavularia viridis.

  • Isolation of three new and seven known xenicane-type diterpenes from Xenia florida.

  • Isolation of ten new and four known verticillane-type diterpenes from Cespitularia taeniata.

  • Isolation of three new and seven known verticillane-type diterpenes from Cespitularia hypotentaculata.

  • Isolation of seven new and two known cembrane-type diterpenes from Cespitularia hypotentaculata.

Other researches (2004-2011)

        • Isolation of twenty new and nineteen known lignans from kadsura philippinensis.

        • Isolation of five new and fifteen known lignans from Schisandra arisanensis Hayata.

        • Isolation of two new compounds from Hypercium geminiflorum.

        • Isolation of three new clerodane-type diterpenes from Casearia membranacea.

        • Isolation of thirty known compounds from several species of sponge.

        • Isolation of new Napyradiomycins from actinomycine.

* Characterization of these compounds used IR, UV, Mass, 1D and 2D-NMR techniques, such as COSY, HMQC, HMBC, NOESY.



* All compounds showed biological activities.
Conferences Attended:


  1. Participated in “The 52nd annual meeting of the American Society of Pharmacognosy” from July 30 to August 3. 2011. San Diego.

  2. Participated in “The 50th annual meeting of the American Society of Pharmacognosy” from June 27 to July 1. 2009. Hawaii.

  3. Participated in “2nd Taiwan-France Workshop on Herbal Medicine” April 16. 2009. Taipei

  4. Participated in “2004 annual meeting of the Chinese Pharmacy Society” December 18. 2004. Taipei.

  5. Participated in “International Biotech Conference & Exhibition” from October 31 to November 25-27. 2004. Kaohsiung.

  6. Participated in “18th International Symposium on Natural Product Chemistry” from October 31 to November 2. 2003. Kaohsiung.


List of Publications (since 2004, total 32 papers published):


  1. Yuan-Bin Cheng, Yu-Chi Lin, Ashraf Taha Khalil, Shorong-Shii Liou, Guo-Chi Lee, Yao-Haur Kuo and Ya-Ching Shen, ” Seven New Lignan Esters from Kadsura philippinensis “,Helv. Chim. Acta, 2011, 94, 148-158.

  2. Yuan-Bin Cheng, Tzu-Ching Liao, Yi-Wen Lo, Yu-Chen Chen, Yuh-Chi Kuo, Shun-Ying Chen, Ching-Te Chien, Tsong-Long Hwang, and Ya-Ching Shen; “Nortriterpene Lactones from the Fruits of Schisandra arisanensis” J. Nat. Prod., 2010, 73, 1228-1233.

  3. Yuan-Bin Cheng, Tzu-Ching Liao, Yi-Wen Lo, Yu-Chen Chen, Yuh-Chi Kuo, Shun-Ying Chen, Ching-Te Chien, and Ya-Ching Shen; “Arisandilactone A, a New Triterpenoid from the Fruits of Schisandra arisanensis”, Org. Lett, 2010, 12, 1016-1019.

  4. Chin-Cheng Liu, Mohamed H. Abd El-Razek, Chia-Ching Liaw, Yuan-Bin Cheng, Chien-Kuang Chen, Ching-Te Chien, Yao-Haur Kuo, Shorong-Shii Liou, and Ya-Ching Shen “Arisanschinins A-E, Lignans from Schisandra arisanensis Hay”, Planta ,medica, 2010, 76, 1-6.

  5. Jiun-Yang Chang, Mohamed H. Abd El-Razek, Yu-Hui Chen, Yuan-Bin Cheng, Shun-Ying Chen, Ching-Te Chien, Yao-Haur Kuo and Ya-Ching Shen; “Phytoquinoids and Secoprezizaane-Type Sesquiterpenes from Illicium arborescens”, Helv. Chim. Acta, 2010, 93, 123-132.

  6. Yuan-Bin Cheng, Meng-Ting Chang, Yi-Wen Lo, Ching-Jen Ho, Yuh-Chi Kuo, Ching-Te Chien, Shun-Ying Chen, Shorong-Shii Liou, Yao-Haur Kuo, and Ya-Ching Shen; “Oxygenated Lignans from the Fruits of Schisandra arisanensis”, J. Nat. Prod., 2009, 72, 1663-1668.

  7. Yuan-Bin Cheng, Ching-Yeu Chen, Ya-Ching Shen; “New Nitrogen-

containing Sesqiterpenoids from the Taiwanese Soft Coral Cespitularia taeniata May”, Chemistry & Biodiversity, 2009, 6, 1266-1272.

  1. Ya-Ching Shen, Yu-Chi Lin, Yuan-Bin Cheng, Michael Y. Chiang, Shorong-Shii Liou, Ashraf Taha Khalil; “Dibenzocyclooctadiene lignans from kadsura philippinensisPhytochemistry, 2009, 70, 114-120.

  2. Yuan-Bin Cheng, Ya-Ching Shen, Yao-Haur Kuo, and Ashraf Taha Khalil; “Cembrane Diterpenoids from the Taiwanese Soft Coral Sarcophyton stolidotum”, J. Nat. Prod., 2008, 71, 1141-1145.

  3. Yuan-Bin Cheng, Kuang-Liang Lo, Ching-Yeu Chen, Ashraf Taha Khalil, and Ya-Ching Shen; “New Verticillane-type Diterpenoids from the Taiwanese Soft Coral Cespitularia hypotentaculata”, Helv. Chim. Acta, 2008, 91, 2308-2315.

  4. Ya-Ching Shen, Yu-Chi Lin, Yuan-Bin Cheng, Chia-Ju Chang, Ting-Wei Lan, Shorong-Shii Liou, Ching-Te Chien, Chia-Ching Liaw, and Ashraf Taha Khalil; “New Oxygenated Lignans from Kadsura philippinensis”, Helv. Chim. Acta, 2008, 91, 483-494.

  5. Ching-Yu Chen, Yuan-Bin Cheng, Shun-Ying Chenc, Ching-Te Chienc, Yao-Haur Kuod, Jih-Hwa Guh, Ashraf Taha Khalile, and Ya-Ching Shen; “New Bioactive Clerodane Diterpenoids from the Roots of Casearia membranacea”, Chemistry & Biodiversity, 2008, 5, 162-167.

  6. Yun-Sheng Lin, Ashraf Taha Khalil, Shih-Hwa Chiou, Yuh-Chi Kuo, Yuan-Bin Cheng, Chia-Ching Liaw, and Ya-Ching Shen; “Bioactive Marine Prostanoids from Octocoral Clavularia viridis”, Chemistry & Biodiversity, 2008, 5, 784-792.

  7. Ya-Ching Shen, Yu-Hui Chen, Yuan-Bin Cheng, Yao Haur Kuo, Ashraf Taha Khalil; “Two new xeniolides from a Taiwanese Xenia soft coral”, Nat. Prod. Res., 2007, 13, 1171-1177.

  8. Ya-Ching Shen, Yuan-Bin Cheng, Jun’ichi Kobayashi, T akaaki Kubota, Yohei Takahashi, Yuzuru Mikami, Junji Ito and Yun-Sheng Lin; “Nitrogen-Containing Verticillene Diterpenoids from the Taiwanese Soft Coral Cespitularia taeniata”, J. Nat. Prod., 2007, 70, 1961-1965.

  9. Ya-Ching Shen, Yuan-Bin Cheng, Ting-Wei Lan, Chia-Ching Liaw, Shorong-Shii Liou, Yao-Haur Kuo,and Ashraf Taha Khalil; “Kadsuphilols A-H, Oxygenated Lignans from Kadsura philippinensis”, J. Nat. Prod., 2007, 70, 1139-1145.

  10. Ya-Ching Shen, Yu-Chi Lin, Atallah F. Ahmed, Yuan-Bin Cheng, Chia-Ching Liaw, and Yao-Haur Kuo; “Four New Nonaoxygenated C18 Dibenzocyclooctadiene Lignans from Kadsura philippinensis”, Chem. Pharm. Bull., 2007, 55, 280-283.

  11. Ya-Ching Shen, Chia-Ching Liaw, Yuan-Bin Cheng, Atallah F. Ahmed, Mei-Chou Lai, Shorong-Shii Liou, Tian-Shung Wu, Yao-Haur Kuo, and Yu-Chi Lin; “C18 Dibenzocyclooctadiene Lignans from Kadsura philippinensis”, J. Nat. Prod., 2006, 69, 963-966.

  12. Yuan-Bin Cheng, Jiun-Yang Jang, Ashraf Taha Khalil, Yao-Haur Kuo, and Ya-Ching Shen; “Xenicane-Type Diterpenes with Cytotoxicity from Xenia florida”, J. Nat. Prod., 2006, 69, 675-678.

  13. Ya-Ching Shen, Yun-Sheng Lin, Yao-Haur Kuo, and Yuan-Bin Cheng; “Cespitulactams A, B, and C, three new nitrogen-containing diterpenes from Cespitularia taeniata May”, Tetrahedron Lett, 2005, 46, 7893-7897.

  14. Ya-Ching Shen, Shaw-Man Hsu, Yun-Sheng Lin, Kuen-Ching Cheng, Ching-Te Chien. Chang-Hung Chou, and Yuan-Bin Cheng; “New Bicyclic Taxane Diterpenoids from Taxus sumatrana”, Chem. Pharm. Bull., 2005, 53, 808-810.

  15. Ya-Ching Shen, Yun-Sheng Lin, Yuan-Bin Cheng, Kuen-Ching Cheng, Ashraf Taha Khalil, Yao-Haur Kuo, Ching-Te Chien and Yu-Chi Lin; “Novel taxane diterpenes from Taxus sumatrana with the first C-21 taxane ester”, Tetrahedron, 2005, 61, 1345-1352.

  16. Ya-Ching Shen, Yuan-Bin Cheng, Atallah F. Ahmed, Cheng Lin Lee, Shun-Ying Chen, Ching-Te Chien, Yao-Haur Kuo, and Guo-Lin Tzeng; “Cytotoxic Clerodane Diterpenoids from Casearia membranacea”, J. Nat. Prod., 2005, 68, 1665-1668.

  17. Ya-Ching Shen, Kuen-Ching Cheng, Yu-Chi Lin, Yuan-Bin Cheng, Ashraf Taha Khalil, Jih-Hwa Guh, Ching-Te Chien, Che-Ming Teng, and Yao-To Chang; “Three New Taxane Diterpenoids from Taxus sumatrana”, J. Nat. Prod., 2005, 68, 90-93.

  18. Ya-Ching Shen, Cheng Lin Lee, Ashraf Taha Khalil, and Yuan-Bin Cheng; “New Clerodane Diterpenes from Casearia membranacea”, Helv. Chim. Acta, 2005, 88, 68-77.

  19. Ya-Ching Shen, Yuan-Bin Cheng, Yu-Hui Chen, Ashraf Taha Khalil, and Chin-Lien Ko; “Three New Clerodane Diterpene Derivatives from Casearia membranacea”, J. Chin. Chem. Soc., 2005, 52, 1263-1268.

  20. Ya-Ching Shen, Yu-Chi Lin, Yuan-Bin Cheng, Yao-Haur Kuo, and Chia-Ching Liao; “Taiwankadsurins A, B, and C, Three New C19 Homolignans from Kadsura philippensis”, Org. Lett, 2005, 7, 5297-5300.

  21. Ya-Ching Shen, Yu-Chi Lin, Michael Y. Chiang, Sheau Farn Yeh, Yuan-Bin Cheng, and Chia-Ching Liao; “Kadsuphilactones A and B, Two New Triterpene Dilactones from Kadsura philippensis”, Org. Lett, 2005, 7, 3307-3310.

  22. Ya-Ching Shen, Chih-Hsin Wang, Yuan-Bin Cheng, Li-Yung Wang, Jih-Hwa Guh, Ching-Te Chien, and Ashraf Taha Khalil; “New Cytotoxic Clerodane Diterpenoids from the Leaves and Twigs of Casearia membranacea”, J. Nat. Prod., 2004, 67, 316-321.

  23. Ya-Ching Shen, Yuan-Bin Cheng, A. T. Khalil, Meng-Hsien Chen and Yu-Chi Lin; “Clavulazols A and B, Two New Pyrazine Derivatives from Clavularia viridis”, J. Chin. Chem. Soc., 2004, 51, 1421-1424.

  24. Ya-Ching Shen, Chin-Lien Ko, Yuan-bin Cheng, Michael Y. Chiang, and Ashraf Taha Khalil; “New Regio- and Stereoselective O-Deacetylated and Epoxy Products of Taxanes Isolated from Taxus mairei”, J. Nat. Prod., 2004, 67, 2136-2140.

  25. Ya-Ching Shen, Yuan-Bin Cheng, Yu-Chi Lin, Jih-Hwa Guh, Che-Ming Teng, and Chin-Lien Ko; “New Prostanoids with Cytotoxic Activity from Taiwanese Octocoral Clavularia viridis”, J. Nat. Prod., 2004, 67, 542-546.

References:


  1. Prof. Ya-Ching Shen

School of Pharmacy, College of Medicine, National Taiwan University

Phone: 886-2-233937083

E-mail: ycshen@ntu.edu.tw


  1. Prof. Yao-Haur Kuo

National Research Institute of Chinese Medicine

Phone: 886-2-8201999

E-mail: kuoyh@nricm.edu.tw 


  1. Prof. Hong-Nong Chou

Institute of Fisheries Science, National Taiwan University

Phone: 886-2- 33662879

E-mail: unijohn@ntu.edu.tw


  1. Prof. Jyh-horng Sheu

Department of Marine Biotechnology and Resources, College of Marine Sciences, Sun Yat-sen University

Phone: 886-7-5252000-5030

E-mail: sheu@mail.nsysu.edu.tw
5. Dr. Oliver McConnell

Project Scientist, Center for Marine Biotechnology and Biomedicine Scripps Institution of Oceanography University of California, San Diego



Phone: 484-844-3499

E-mail: omcconnell@ucsd.edu


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