Additional file avexis classifications




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Additional file 6.
AVEXIS classifications:
A: Homophilic interaction seen in both the primary and validation screens.
C: Heterophilic interaction positive in both bait:prey orientations in the primary and validation screens. Positive 4 out of 4 times tested.
D: Heterophilic interaction positive in both bait:prey orientations in either the primary or validation screens. Positive 3 out of 4 times tested.
E: Heterophilic interaction positive in one bait:prey orientation in the primary screen but other orientation not tested; positive in both orientations in the validation screen. Positive 3 out of 3 times tested.
F: Heterophilic interaction positive in one bait:prey orientation in the primary screen but other orientation not tested; also positive in one orientation only in validation screen (both tested) but in different orientation to the primary screen. Positive 2 out of 3 times tested.
G: Heterophilic interaction positive in one bait:prey orientation only in both the primary and validation screen. Positive 2 out of 4 times tested.
H: Heterophilic interaction negative in both bait:prey orientations in the primary screen but positive in both orientations in the validation screen. Positive 2 out of 4 times tested.
I: Heterophilic interaction positive in one bait:prey orientation in the primary screen but other orientation not tested; positive in only the same orientation in the validation sceen (both tested). Positive 2 out of 3 times tested.
J: Heterophilic interaction negative in the one tested bait:prey orientation in the primary screen but positive in both orientations in the validation screen. Positive 2 out of 3 times tested.
K: Heterophilic interaction positive in both bait:prey orientations in the primary screen but not seen in the validation screens. Positive 2 out of 4 times tested.
L: Heterophilic interaction positive in one bait:prey orientation in the primary screen; positive in the other orientation in the validation screen. Positive 2 out of 4 times tested.
Note that in AVEXIS classes G and I, the interaction is bait:prey orientation dependent. In these cases, the bait is listed as protein 1 and the prey as protein 2



Interaction number


Interaction

AVEXIS

Class

IntAct accession number

Protein 1

Protein 2

Bait (1)-prey (2)

Bait(2)-prey(1)

High confidence
















Homophilic
















1

Lrrtm2




A

EBI-2263346

N/A

2

Lrrtm1




A

EBI-2263359

N/A

3

Flrt1a




A

EBI-2263370

N/A

4

Lrrtm4l1




A

EBI-2263381

N/A

5

Lrrtm4l2




A

EBI-2263394

N/A

Heterophilic
















6

Lrrn1

Lrrc4c

C

EBI-2263409

EBI-2263557

7

Unc5b

Flrt1b

C

EBI-2263420

EBI-2263570

8

Unc5b

Flrt1a

C

EBI-2263433

EBI-2263579

9

Islr2

Vasn

C

EBI-2263446

EBI-2263588

10

Lrrtm2

Lrrtm1

C

EBI-2263455

EBI-2263599

11

Lrrtm1

Lrrtm4l1

C

EBI-2263464

EBI-2263608

12

Lrrtm1

Lrrtm4l2

C

EBI-2263473

EBI-2263617

13

Unc5b

Flrt3

D

EBI-2263484

EBI-2263628

14

Unc5b

Islr2

D

EBI-2263493

EBI-2263639

15

Lrrtm1

Fgfrl1b

D

EBI-2263504

EBI-2263648

16

Lrrtm4l1

Lrrtm4l2

D

EBI-2263513

EBI-2263659

17

Elfn2

IgSF21

E

EBI-2263522

EBI-2263670

18

Lrrtm1

Boc

E

EBI-2263537

EBI-2263679

19

Lrrtm1

Fgfrl1a

E

EBI-2263548

EBI-2263692

20

Elfn1

Robo3

F

EBI-2263725

EBI-2263701

21

Lrrtm4l1

Boc

F

EBI-2263734

EBI-2263714

Lower confidence
















Heterophilic
















22

Lingo1a

Lingo1b

G

EBI-2263745

N/A

23

Lrrn1

Lrrc4a

G

EBI-2263758

N/A

24

Lrrtm2

Lrrtm4l2

G

EBI-2263767

N/A

25

Lrrc24

Robo2

G

EBI-2263776

N/A

26

Lrrtm1

Rtn4rl1

H

EBI-2263789

EBI-2263880

27

Lrrtm4l1

Lrrc24

H

EBI-2263800

EBI-2263889

28

Flrt3

Mag

H

EBI-2263811

EBI-2263898

29

Elfn2

Boc

I

EBI-2263820

N/A

30

Flrt3

Boc

I

EBI-2263829

N/A

31

Lrrtm1

Fgfr4

J

EBI-2263840

EBI-2263909

32

Robo2

Lrrtm1

K

EBI-2263851

EBI-2263920

33

Lrrtm2

Lrrtm4l1

K

EBI-2263860

EBI-2263929

34

Lrrtm1

Mag

L

EBI-2263869

EBI-2263938


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