Activity of fungal endophytes against Plasmodium falciparum




Дата канвертавання19.04.2016
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Table S1: Activity of fungal endophytes against Plasmodium falciparum (causative agent of malaria) in in vitro assays, organized by host plant family. Data indicate mean percent inhibition of growth (mean % IG) of parasite cells and standard error, the number of plant species and fungal genotypes examined, the number and percent of fungal genotypes that are highly active (i.e. ≥ 50 % IG), and a qualitative statement of activity level. Mean % IG varied significantly between activity levels (F2,137 = 4.67; p = 0.0108).

Family (Order)

Mean %IG (± SE)

Plant Species Examined

Fungal Genotypes Examined

Highly Active Genotypes

% Highly Active Genotypes

Activity Level

Bignoniaceae (Scrophulariales)

51.1 (11.4)

3

6

3

50

High

Clusiaceae (Malpighiales)

38.5 (14)

3

4

2

50

High

Fabaceae (Fabales)

25.5 (4.2)

13

36

10

27.8

High

Apocynaceae (Gentianales)

19.7 (7)

3

14

2

14.3

Moderate

Rubiaceae (Gentianales)

17.8 (7)

10

14

2

14.3

Moderate

Euphorbiaceae (Malpighiales)

16.1 (9.9)

4

8

1

12.5

Moderate

Verbenaceae (Lamiales)

15.9 (7.8)

4

13

1

7.7

Moderate

Annonaceae (Magnoliales)

12.4 (8.9)

3

9

1

11.1

Moderate

Araceae (Alismatales)

10.6 (10.6)

3

7

1

14.3

Moderate

Moraceae (Rosales)

9.6 (7.2)

4

14

0

0

Low


Table S2: Activity of fungal endophytes against Leishmania donovani (causative agent of leishmaniasis) in in vitro assays, organized by host plant family. Data indicate mean percent inhibition of growth (mean % IG) of parasite cells and standard error, the number of plant species and fungal genotypes examined, the number and percent of fungal genotypes that are highly active (i.e. ≥ 50 % IG), and a qualitative statement of activity level. Mean % IG varied significantly between activity levels (F2,194 = 4.86; p = 0.0087).

Family (Order)

Mean %IG (± SE)

Plant Species Examined

Fungal Genotypes Examined

Highly Active Genotypes

% Highly Active Genotypes

Activity Level

Bignoniaceae (Scrophulariales)

24.8 (9.2)

3

6

0

0

High

Rubiaceae (Gentianales)

21.9 (4.1)

10

25

2

8

High

Apocynaceae (Gentianales)

20 (5.3)

3

17

2

11.8

High

Verbenaceae (Lamiales)

17.6 (4.7)

5

22

3

13.6

Moderate

Araceae (Alismatales)

15.8 (7.5)

4

9

1

11.1

Moderate

Moraceae (Rosales)

15.1 (4.6)

5

20

2

10

Moderate

Fabaceae (Fabales)

14.9 (3.2)

15

41

4

9.8

Moderate

Euphorbiaceae (Malpighiales)

9.4 (6.2)

3

12

0

0

Low

Clusiaceae (Malpighiales)

6.2 (6)

3

13

0

0

Low

Annonaceae (Magnoliales)

4.4 (7.1)

3

9

0

0

Low


Table S3: Activity of fungal endophytes against Trypanosoma cruzi (causative agent of Chagas’ disease) in in vitro assays, organized by host plant family. Data indicate mean percent inhibition of growth (mean % IG) of parasite cells and standard error, the number of plant species and fungal genotypes examined, the number and percent of fungal genotypes that are highly active (i.e. ≥ 50 % IG), and a qualitative statement of activity level. Mean % IG varied significantly between activity levels (F1,181 = 4.20; p = 0.0428).

Family (Order)

Mean %IG (± SE)

Plant Species Examined

Fungal Genotypes Examined

Highly Active Genotypes

% Highly Active Genotypes

Activity Level

Fabaceae (Fabales)

20.8 (2.3)

15

39

6

15.4

High

Rubiaceae (Gentianales)

20.8 (3.1)

10

23

3

13.1

High

Bignoniaceae (Scrophulariales)

20.6 (6.7)

3

6

0

0

High

Araceae (Alismatales)

19.8 (5.5)

4

9

1

11.1

Moderate

Apocynaceae (Gentianales)

17.8 (3.9)

3

17

1

5.9

Moderate

Euphorbiaceae (Malpighiales)

16.8 (4.9)

3

11

0

0

Moderate

Clusiaceae (Malpighiales)

15.5 (4.7)

3

12

0

0

Moderate

Verbenaceae (Lamiales)

15.3 (3.3)

5

22

1

4.5

Moderate

Moraceae (Rosales)

15.1 (3.8)

5

16

1

6.3

Moderate

Annonaceae (Magnoliales)

10.9 (5.8)

3

8

0

0

Moderate


Table S4: Activity of fungal endophytes against MCF-7 breast cancer cells in in vitro assays, organized by host plant family. Data indicate mean percent inhibition of growth (mean % IG) of parasite cells and standard error, the number of plant species and fungal genotypes examined, the number and percent of fungal genotypes that are highly active (i.e. ≥ 50 % IG), and a qualitative statement of activity level. Mean % IG varied significantly between activity levels (F2,171 = 4.49; p = 0.0125).

Family (Order)

Mean %IG (± SE)

Plant Species Examined

Fungal Genotypes Examined

Highly Active Genotypes

% Highly Active Genotypes

Activity Level

Araceae (Alismatales)

27.6 (10.7)

3

5

1

20

High

Fabaceae (Fabales)

16.5 (3.7)

11

36

6

16.7

Moderate

Rubiaceae (Gentianales)

16.3 (4.5)

10

23

4

17.4

Moderate

Moraceae (Rosales)

13.6 (4.9)

5

20

2

10

Moderate

Apocynaceae (Gentianales)

10.9 (6)

3

16

1

6.3

Moderate

Bignoniaceae (Scrophulariales)

10.8 (11.9)

3

4

0

0

Moderate

Verbenaceae (Lamiales)

6.3 (5.2)

5

20

0

0

Low

Annonaceae (Magnoliales)

6.3 (9)

3

7

0

0

Low

Clusiaceae (Malpighiales)

3.8 (6.2)

4

13

0

0

Low

Euphorbiaceae (Malpighiales)

3 (6.9)

3

12

0

0

Low


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